التفاصيل البيبلوغرافية
| العنوان: |
Platelet count, aspirin use, and characteristics of host inflammatory responses in colorectal cancer. |
| المؤلفون: |
Väyrynen, Juha P., Väyrynen, Sara A., Sirniö, Päivi, Minkkinen, Ilkka, Klintrup, Kai, Karhu, Toni, Mäkelä, Jyrki, Herzig, Karl-Heinz, Karttunen, Tuomo J., Tuomisto, Anne, Mäkinen, Markus J. |
| المصدر: |
Journal of Translational Medicine; 6/13/2019, Vol. 17 Issue 1, pN.PAG-N.PAG, 1p |
| مصطلحات موضوعية: |
COLORECTAL cancer, BLOOD platelets, ASPIRIN, PLATELET count, CARCINOGENESIS, LEUCOCYTE elastase |
| مستخلص: |
Background: Platelets not only contribute to hemostasis but also to the regulation of inflammatory reactions and cancer pathogenesis. We hypothesized that blood platelet count would be associated with systemic inflammation, the densities of tumor infiltrating immune cells, and survival in colorectal cancer (CRC), and these relationships could be altered by aspirin use.Methods: We measured blood platelet count in a cohort of 356 CRC patients and analyzed its relationships with tumor and patient characteristics including aspirin use, markers of systemic inflammation (modified Glasgow Prognostic Score, mGPS; serum levels of CRP, albumin, and 13 cytokines), blood hemoglobin levels, five types of tumor infiltrating immune cells (CD3, CD8, FoxP3, Neutrophil elastase, mast cell tryptase), and survival.Results: Platelet count inversely correlated with blood hemoglobin levels (p < 0.001) and positively correlated with serum levels of CRP and multiple cytokines including IL-1RA, IL-4, IL-6, IL-7, IL-8, IL-12, IFNγ, and PDGF-BB (p < 0.001 for all), while aspirin use was not associated with the levels of systemic inflammatory markers. High platelet count was also associated with high mGPS (p < 0.001) but did not show statistically significant multivariable adjusted associations with the densities of tumor infiltrating immune cells. Higher platelet counts were observed in higher tumor stage (p < 0.001), but platelet count or aspirin use were not associated with patient survival.Conclusions: High platelet count is associated with systemic inflammation in CRC. This study could not demonstrate statistically significant associations between platelet count, aspirin use, and the densities of tumor infiltrating immune cells. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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