Predictors and Temporal Trends of Adjuvant Aromatase Inhibitor Use in Breast Cancer
| العنوان: | Predictors and Temporal Trends of Adjuvant Aromatase Inhibitor Use in Breast Cancer |
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| المؤلفون: | Michael A. Bookman, Richard L. Theriault, Rebecca A. Ottesen, Joyce C. Niland, Tiffany H. Svahn, Stephen B. Edge, Anne F. Schott, Melissa E. Hughes, Robert W. Carlson, Jane C. Weeks |
| المصدر: | Journal of the National Comprehensive Cancer Network. 7:115-121 |
| بيانات النشر: | Harborside Press, LLC, 2009. |
| سنة النشر: | 2009 |
| مصطلحات موضوعية: | Adult, Selective Estrogen Receptor Modulators, Oncology, medicine.medical_specialty, Neoplasms, Hormone-Dependent, Antineoplastic Agents, Hormonal, Receptor, ErbB-2, medicine.drug_class, medicine.medical_treatment, Breast Neoplasms, Breast cancer, Internal medicine, medicine, Adjuvant therapy, Humans, Practice Patterns, Physicians', Aged, Randomized Controlled Trials as Topic, Aged, 80 and over, Aromatase inhibitor, Aromatase Inhibitors, business.industry, Vascular disease, Cancer, Middle Aged, medicine.disease, Gene Expression Regulation, Neoplastic, Postmenopause, Tamoxifen, Logistic Models, Endocrinology, Chemotherapy, Adjuvant, Female, business, Adjuvant, medicine.drug, Hormone |
| الوصف: | After the first report of the ATAC (Arimidex, Tamoxifen, Alone or in Combination) trial, adjuvant aromatase inhibitor use increased rapidly among National Comprehensive Cancer Network member institutions. Increased aromatase inhibitor use was associated with older age, vascular disease, overexpression of human epidermal growth factor receptor 2 (HER2), or more advanced stage, and substantial variation was seen among institutions. This article examines adjuvant endocrine therapy in postmenopausal women after the first report of the trial, identifies temporal relationships in aromatase inhibitor use, and examines characteristics associated with choice of endocrine therapy among 4044 postmenopausal patients with hormone receptor-positive nonmetastatic breast cancer presenting from July 1997 to December 2004. Multivariable logistic regression analysis examined temporal associations and characteristics associated with aromatase inhibitor use. Time-trend analysis showed increased aromatase inhibitor and decreased tamoxifen use after release of ATAC results (P < .0001). In multivariable regression analysis, institution (P |
| تدمد: | 1540-1413 1540-1405 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::603ebc5218668b0ab68de74db96c5a00Test https://doi.org/10.6004/jnccn.2009.0011Test |
| رقم الانضمام: | edsair.doi.dedup.....603ebc5218668b0ab68de74db96c5a00 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15401413 15401405 |
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