The effect of L-arginine therapy on hepatocyte cells damage in mice (Mus musculus) model of preeclampsia
| العنوان: | The effect of L-arginine therapy on hepatocyte cells damage in mice (Mus musculus) model of preeclampsia |
|---|---|
| المؤلفون: | Sri Sulistyowati, Bambang Arinekso, Soetrisno Soetrisno |
| المصدر: | Journal of the Medical Sciences (Berkala ilmu Kedokteran); Vol 51, No 4 (2019); 316-324 Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 51, No 4 (2019); 316-324 Journal of the Medical Sciences, Vol 51, Iss 4 (2019) |
| بيانات النشر: | Journal of the Medical Sciences (Berkala ilmu Kedokteran), 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | lcsh:R5-920, medicine.medical_specialty, Fetus, Arginine, business.industry, lcsh:R, lcsh:Medicine, Histology, medicine.disease, female genital diseases and pregnancy complications, Preeclampsia, Andrology, Experimental animal, l-arginine - hepatocytes cell - preeclampsia - mouse model - animal model, medicine.anatomical_structure, Hepatocyte, embryonic structures, Medicine, Histopathology, L-arginine, hepatocytes cell, preeclampsia, mouse model, animal model, Endothelial dysfunction, lcsh:Medicine (General), business, reproductive and urinary physiology |
| الوصف: | Preeclampsia is one of the main contributors on morbidity and mortality of mother and fetus. Imbalance of body antioxidants and oxidants has a role on endothelial destruction causing endothelial dysfunction which leads to preeclampsia. L-arginine administration is indicated to be able to fix the remodelling process of hepatocytes which was damaged on preeclampsia. The aim of this study was to investigate the effect of L-arginine on hepatocyte cells damage on mouse ( Mus musculus ) model of preeclampsia. Experimental study was conducted in the Experimental Animal Warehouse and Biomedical Laboratory, Faculty of Veterinary Medicine, Airlangga University, Surabaya. A total of 30 pregnant mice were divided into three groups with 10 mice in each group i.e. normal, preeclampsia model and preeclampsia model with L-arginine therapy pregnant mice. Preparates were taken from dissected mice liver, with prior paraffin block and were then stained with hematoxylin-eosin. Results were analyzed semi quantitatively with Manja Roenigk hepar histology scoring method. Data were analyzed using Kruskal-Wallis and Man-Whitney test. Mean of hepar histopathology score of preeclampsia model with L-arginine therapy (40.80±1.17/µm 2 ) was significantly lower compared with preeclampsia model pregnant mice (58.80±4.23/µm 2 ) (p |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 0126-1312 2356-3931 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1110dc6895c411b39758184056c9d7feTest https://journal.ugm.ac.id/bik/article/view/27679Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....1110dc6895c411b39758184056c9d7fe |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 01261312 23563931 |
|---|