Correlation between the molecular subtype of breast cancer and the in vitro adenosine triphosphate-based chemosensitivity assay
| العنوان: | Correlation between the molecular subtype of breast cancer and the in vitro adenosine triphosphate-based chemosensitivity assay |
|---|---|
| المؤلفون: | Woosung Lim, Sun Hee Sung, Jihyun Lee, Anbok Lee, Byung In Moon, Jina Chang |
| المصدر: | Journal of the Korean Surgical Society |
| بيانات النشر: | The Korean Surgical Society, 2013. |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | Oncology, medicine.medical_specialty, Chemotherapy, business.industry, medicine.medical_treatment, Cancer, Pharmacology, medicine.disease, Chemotherapy regimen, In vitro, Adjuvant chemotherapy, chemistry.chemical_compound, Breast cancer, chemistry, Hormone receptor, Internal medicine, medicine, Surgery, Original Article, Breast neoplasms, business, Chemosensitivity assay, Adenosine triphosphate |
| الوصف: | Purpose: The empirical use of a chemotherapy regimen shows different results in individual breast cancer patient treatment. Recent studies showed the effectiveness of the adenosine triphosphate-based chemotherapy response assay (ATP-CRA). However, little is known about the correlation between chemosensitivity and breast cancer molecular subtypes. Therefore, we investigated whether the result of ATP-CRA is associated with a molecular subtype of breast cancer. Methods: Two hundred eighty-seven patients diagnosed with breast cancer and receiving ATP-CRA at Mokdong Hospital, Ewha Womans University between September 2007 and December 2010 were enrolled in this study. Hormone receptor status, HER2/neu expression, and results of chemosensitivity tests of the patients was analyzed. Results: In all of four subtypes, the combination of two agents showed significant higher mean cell death rate than a single agent. Within the breast cancer cell lines in this study, the range of chemosensitivity response was very wide and varied for each patient. For this reason, the molecular subtype of breast cancer is inconclusive in choosing an effective chemotherapeutic agent and in vitro chemosensitivity test, prior to therapy, could be a useful method for planning chemotherapy for each patient. Conclusion: Chemosensitivity response to anticancer agents was found to vary depending on the individual breast cancer patients. The molecular subtype of breast cancer is inconclusive to choose the effective chemotherapeutic agent and the in vitro chemosensitivity test, prior to therapy, could be more useful for planning chemotherapy for each patient. |
| اللغة: | English |
| تدمد: | 2093-0488 2233-7903 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccadd57ed07d0719674538c16a4e5c31Test http://europepmc.org/articles/PMC3670999Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....ccadd57ed07d0719674538c16a4e5c31 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20930488 22337903 |
|---|