التفاصيل البيبلوغرافية
| العنوان: |
Anti‐β4 integrin autoantibodies in patients with mucous membrane pemphigoid: A retrospective analysis from a tertiary centre in Italy. |
| المؤلفون: |
Maglie, Roberto, De Almeida, Carolina Vieira, Baffa, Maria Efenesia, Bianchi, Beatrice, Caproni, Marzia, Di Zenzo, Giovanni, Li, Xiaoguang, Hirako, Yoshiaki, Hashimoto, Takashi, Tusa, Ignazia, Lulli, Matteo, Rovida, Elisabetta, Antiga, Emiliano |
| المصدر: |
Journal of the European Academy of Dermatology & Venereology; Feb2023, Vol. 37 Issue 2, pe249-e251, 3p |
| مصطلحات موضوعية: |
MUCOUS membranes, INTEGRINS, AUTOANTIBODIES, BULLOUS pemphigoid, RETROSPECTIVE studies, MOLECULAR weights |
| مصطلحات جغرافية: |
ITALY |
| مستخلص: |
Mucous membrane pemphigoid (MMP) is a rare mucosal-dominant subepidermal autoimmune bullous disease, characterized by autoantibodies targeting different basement membrane zone (BMZ) molecules, including collagen XVII (BP180), laminin 332 and collagen VII.[1] A limited number of studies suggested 4 integrin as a relevant autoantigen of MMP,[[2], [4], [6]] especially of ocular MMP, but the prevalence of these autoantibodies in MMP remains elusive.[[1], [7]] Although searching for anti- 4 integrin antibodies is not yet recommended for the diagnosis of MMP, current guidelines strongly advice more investigations to clarify this issue.[9] In this 3-year monocentric retrospective study started in January 2018 (Ethical approval CEAVC 21730), we retrieved serum samples from 40 patients who were diagnosed with MMP, according to current guidelines.[9] Anamnestic, clinical and immunopathological features of patients are reported in Table 1. Representative images from two patients positive for anti- 4 integrin antibodies as well as one patient and a healthy control negative for anti- 4 integrin antibodies were shown. Unexpectedly, among the six patients, whose sera reacted with 4 integrin proteins, four patients exclusively showed oral disease, while two patients were multisite MMP including ocular involvement. [Extracted from the article] |
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| قاعدة البيانات: |
Complementary Index |
