دورية
Reduced Glomerular Filtration in Diabetes Is Attributable to Loss of Density and Increased Resistance of Glomerular Endothelial Cell Fenestrations
| العنوان: | Reduced Glomerular Filtration in Diabetes Is Attributable to Loss of Density and Increased Resistance of Glomerular Endothelial Cell Fenestrations |
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| المؤلفون: | Finch, Natalie C., Fawaz, Sarah S., Neal, Chris R., Butler, Matthew J., Lee, Vivian K., Salmon, Andrew J., Lay, Abigail C., Stevens, Megan, Dayalan, Lusyan, Band, Hamid, Mellor, Harry H., Harper, Steven J., Shima, David T., Welsh, Gavin I., Foster, Rebecca R., Satchell, Simon C. |
| المصدر: | Journal of the American Society of Nephrology; June 2022, Vol. 33 Issue: 6 p1120-1136, 17p |
| مستخلص: | We propose a novel mechanism underlying loss of renal filtration function from studying glomerular endothelial cell (GEnC) fenestrae in human diabetic kidney tissue and in a mouse model of diabetes. Diaphragmed fenestrae may provide structural resistance to filtration. We hypothesize that EHD3 is a key regulator of GEnC fenestrations, and its glomerular expression is lost in diabetes. This study establishes the critical role of GEnC fenestrations in renal filtration function and suggests a key regulator, potentially paving the way for development of targeted therapies to restore fenestrae and thus filtration function in kidney disease. |
| قاعدة البيانات: | Supplemental Index |
Full Text Finder | تدمد: | 10466673 15333450 |
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| DOI: | 10.1681/ASN.2021030294 |