Impaired β-Oxidation and Altered Complex Lipid Fatty Acid Partitioning with Advancing CKD
| العنوان: | Impaired β-Oxidation and Altered Complex Lipid Fatty Acid Partitioning with Advancing CKD |
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| المؤلفون: | Keith Bellovich, Jaeman Byun, Jennifer Hawkins, Stefanie Wernisch, Subramaniam Pennathur, Debbie S. Gipson, Tanu Soni, Kelli M. Sas, Farsad Afshinnia, Thekkelnaycke M. Rajendiran, George Michailidis |
| المصدر: | Journal of the American Society of Nephrology. 29:295-306 |
| بيانات النشر: | Ovid Technologies (Wolters Kluwer Health), 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | 0301 basic medicine, chemistry.chemical_classification, medicine.medical_specialty, Fatty acid, Lipid metabolism, General Medicine, 03 medical and health sciences, 030104 developmental biology, Endocrinology, chemistry, Biochemistry, Nephrology, Internal medicine, Plasma lipids, medicine, lipids (amino acids, peptides, and proteins) |
| الوصف: | Studies of lipids in CKD, including ESRD, have been limited to measures of conventional lipid profiles. We aimed to systematically identify 17 different lipid classes and associate the abundance thereof with alterations in acylcarnitines, a metric of β-oxidation, across stages of CKD. From the Clinical Phenotyping Resource and Biobank Core (CPROBE) cohort of 1235 adults, we selected a panel of 214 participants: 36 with stage 1 or 2 CKD, 99 with stage 3 CKD, 61 with stage 4 CKD, and 18 with stage 5 CKD. Among participants, 110 were men (51.4%), 64 were black (29.9%), and 150 were white (70.1%), and the mean (SD) age was 60 (16) years old. We measured plasma lipids and acylcarnitines using liquid chromatography-mass spectrometry. Overall, we identified 330 different lipids across 17 different classes. Compared with earlier stages, stage 5 CKD associated with a higher abundance of saturated C16-C20 free fatty acids (FFAs) and long polyunsaturated complex lipids. Long-chain-to-intermediate-chain acylcarnitine ratio, a marker of efficiency of β-oxidation, exhibited a graded decrease from stage 2 to 5 CKD (P |
| تدمد: | 1533-3450 1046-6673 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::afc9c6396f54a84be4dcc5672058b565Test https://doi.org/10.1681/asn.2017030350Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi...........afc9c6396f54a84be4dcc5672058b565 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15333450 10466673 |
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