التفاصيل البيبلوغرافية
| العنوان: |
The Relationship Between Plasma Levels of Oxidized and Reduced Thiols and Early Atherosclerosis in Healthy Adults |
| المؤلفون: |
Ashfaq, Salman1, Abramson, Jerome L.2, Jones, Dean P.3, Rhodes, Steven D.2, Weintraub, William S.2, Hooper, W. Craig4, Vaccarino, Viola2, Harrison, David G.2, Quyyumi, Arshed A.2 aquyyum@emory.edu |
| المصدر: |
Journal of the American College of Cardiology (JACC). Mar2006, Vol. 47 Issue 5, p1005-1011. 7p. |
| مصطلحات موضوعية: |
*VASCULAR diseases, *OXIDATIVE stress, *ATHEROSCLEROSIS, *ARTERIOSCLEROSIS, *GLUTATHIONE, *CHOLESTEROL, *ISOPENTENOIDS, *C-reactive protein, *BODY weight |
| مستخلص: |
Objectives: The study investigated the relationship between biomarkers of oxidative stress and early atherosclerosis. Background: Oxidative stress is an important etiologic factor in the pathogenesis of vascular disease. We hypothesized that oxidative stress would predict early atherosclerosis in a relatively healthy population. Methods: One hundred fourteen healthy non-smokers, without known clinical atherosclerosis, had carotid intima-media thickness (IMT) measured using ultrasound. Oxidative stress was estimated by measuring plasma levels of: 1) glutathione (GSH), an important intracellular antioxidant thiol, its oxidized disulfide form (GSSG), and their redox state (Eh GSH/GSSG), and 2) cysteine (Cys), an important extracellular antioxidant thiol, its oxidized disulfide form cystine (CySS), and their redox state (EhCys/CySS). Results: The univariate predictors of IMT were age, body mass index, low-density lipoprotein cholesterol, triglycerides, high-density lipoprotein cholesterol, high-sensitivity C-reactive protein (hs-CRP), and Framingham risk score. Intima-media thickness was also higher in males and hypertensive subjects. Among the oxidative stress markers, GSH (r = −0.39, p < 0.0001), CySS (r = 0.18, p = 0.049), and Eh GSH/GSSG (r = 0.34, p < 0.0002) correlated with IMT. After adjusting for traditional risk factors and hs-CRP, only Eh GSH/GSSG remained an independent predictor of IMT. Eh GSH/GSSG predicted IMT in a manner that was both independent of and additive to Framingham risk score. Conclusions: Glutathione redox state (Eh GSH/GSSG), an in vivo measure of intracellular oxidative stress, is an independent predictor for the presence of early atherosclerosis in an otherwise healthy population. This finding supports a role for oxidative stress in the pathogenesis of premature atherosclerosis, and its measurement may help in the early identification of asymptomatic subjects at risk of atherosclerotic disease. [Copyright &y& Elsevier] |
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