التفاصيل البيبلوغرافية
| العنوان: |
Autologous skeletal myoblast transplantation for severe postinfarction left ventricular dysfunction |
| المؤلفون: |
Menasché, Philippe1 philippe.menasche@hop.egp.ap-hop-paris.fr, Hagège, Albert A.2, Vilquin, Jean-Thomas3, Desnos, Michel2, Abergel, Eric2, Pouzet, Bruno1, Bel, Alain1, Sarateanu, Sorin1, Scorsin, Marcio1, Schwartz, Ketty3, Bruneval, Patrick4, Benbunan, Marc5, Marolleau, Jean-Pierre5, Duboc, Denis6, Menasché, Philippe7 (AUTHOR), Hagège, Albert A (AUTHOR) |
| المصدر: |
Journal of the American College of Cardiology (JACC). Apr2003, Vol. 41 Issue 7, p1078-1083. 6p. |
| مصطلحات موضوعية: |
*MYOBLASTS, *LEFT heart ventricle, *CORONARY heart disease complications, *CORONARY heart disease surgery, *LEFT heart ventricle surgery, *STEM cell transplantation, *HEART ventricle diseases, *AUTOGRAFTS, *BIOLOGICAL assay, *CELL culture, *CORONARY artery bypass, *DOPPLER echocardiography, *CARDIAC surgery, *HEART failure, *IMPLANTABLE cardioverter-defibrillators, *SAFETY, *SURGICAL complications, *PILOT projects, *VENTRICULAR tachycardia, *CYTOMETRY, *TREATMENT effectiveness, *STROKE volume (Cardiac output), *THERAPEUTICS |
| مستخلص: |
: ObjectivesThis phase I trial was designed to assess the feasibility and safety of autologous skeletal myoblast transplantation in patients with severe ischemic cardiomyopathy.: BackgroundExperimentally, myoblast grafting into postinfarction myocardial scars improves left ventricular function.: MethodsTen patients were included on the basis of the following criteria: 1) severe left ventricular dysfunction (ejection fraction ≤35%); 2) the presence of a postinfarction akinetic and nonviable scar, as assessed by dobutamine echocardiography and 18-fluorodeoxyglucose positron emission tomography; and 3) an indication of coronary bypass in remote areas. Skeletal myoblasts were grown from a biopsy taken at the thigh.: ResultsAn average of 871 × 106 cells (86% of myoblasts) were obtained after a mean period of 16 days and implanted uneventfully across the scar at the time of bypass. Except for one patient whose early death was unrelated to the cell transplantation, all patients had an uncomplicated postoperative course. Four patients showed delayed episodes of sustained ventricular tachycardia and were implanted with an internal defibrillator. At an average follow-up of 10.9 months, the mean New York Heart Association functional class improved from 2.7 ± 0.2 preoperatively to 1.6 ± 0.1 postoperatively (p < 0.0001), and the ejection fraction increased from 24 ± 1% to 32 ± 1% (p < 0.02). A blinded echocardiographic analysis showed that 63% of the cell-implanted scars (14 of 22) demonstrated improved systolic thickening. One noncardiac death occurred 17.5 months after transplantation.: ConclusionsThese preliminary data suggest the feasibility and safety of autologous skeletal myoblast transplantation in severe ischemic cardiomyopathy, with the caveat of an arrhythmogenic potential. New-onset contraction of akinetic and nonviable segments suggests a functional efficacy that requires confirmation by randomized studies. [Copyright &y& Elsevier] |
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