التفاصيل البيبلوغرافية
| العنوان: |
Diastereomeric Spirooxindoles as Highly Potent and Efficacious MDM2 Inhibitors. |
| المؤلفون: |
Yujun Zhao1, Liu Liu1, Wei Sun1, Jianfeng Lu1, Donna McEachern1, Xiaoqin, Li2, Shanghai Yu1, Bernard, Denzil1, Ochsenbein, Philippe3, Ferey, Vincent3, Carry, Jean-Christophe4, Deschamps, Jeffrey R.5, Sun, Duxin2, Shaomeng Wang1 shaomeng@umich.edu |
| المصدر: |
Journal of the American Chemical Society. 5/15/2013, Vol. 135 Issue 19, p7223-7234. 12p. |
| مصطلحات موضوعية: |
*OXINDOLES, *UBIQUITIN-protein ligase regulation, *P53 protein, *PROTEIN-protein interactions, *PROTEIN metabolism inhibitors, *DIASTEREOISOMERS, *ANTINEOPLASTIC agents |
| مستخلص: |
Small-molecule inhibitors that block the MDM2-p53 protein-protein interaction (MDM2 inhibitors) are being intensely pursued as a new therapeutic strategy for cancer treatment. We previously published a series of spirooxindole-containing compounds as a new class of MDM2 small-molecule inhibitors. We report herein a reversible ring-opening-cyclization reaction for some of these spirooxindoles, which affords four diastereomers from a single compound. Our biochemical binding data showed that the stereochemistry in this class of compounds has a major effect on their binding affinities to MDM2, with >100-fold difference between the most potent and the least potent stereoisomers. Our study has led to the identification of a set of highly potent MDM2 inhibitors with a stereochemistry that is different from that of our previously reported compounds. The most potent compound (MI-888) binds to MDM2 with a Ki value of 0.44 nM and achieves complete and long-lasting tumor regression in an animal model of human cancer. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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