Total Synthesis of (+)-Pleuromutilin
| العنوان: | Total Synthesis of (+)-Pleuromutilin |
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| المؤلفون: | Felix Schäfers, Sean S. Feng, Elliot P. Farney, Sarah E. Reisman |
| المصدر: | Journal of the American Chemical Society. 140:1267-1270 |
| بيانات النشر: | American Chemical Society (ACS), 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 010405 organic chemistry, Extramural, Chemistry, Molecular Conformation, Total synthesis, Stereoisomerism, General Chemistry, 010402 general chemistry, Ring (chemistry), 01 natural sciences, Biochemistry, Combinatorial chemistry, Article, Catalysis, 0104 chemical sciences, Stereocenter, chemistry.chemical_compound, Colloid and Surface Chemistry, Stereospecificity, Polycyclic Compounds, Stereoselectivity, Diterpenes, Pleuromutilin |
| الوصف: | An 18-step synthesis of the antibiotic (+)-pleuromutilin is disclosed. The key steps of the synthesis include a highly stereoselective SmI2-mediated cyclization to establish the eight-membered ring, and a stereospecific transannular [1,5]-hydrogen atom transfer to set the C10 stereocenter. This strategy was also used to prepare (+)-12-epi-pleuromutilin. The chemistry described here will enable efforts to prepare new mutilin antibiotics. |
| وصف الملف: | application/pdf; application/zip |
| تدمد: | 1520-5126 0002-7863 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5db7f9f1c42ad5d550c872798ede6aaTest https://doi.org/10.1021/jacs.7b13260Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....d5db7f9f1c42ad5d550c872798ede6aa |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15205126 00027863 |
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