دورية أكاديمية
أعرض في EDS

Epilepsy drugs and effects on fetal development: Potential mechanisms

التفاصيل البيبلوغرافية
العنوان: Epilepsy drugs and effects on fetal development: Potential mechanisms
المؤلفون: Leila Etemad, Mohammad Moshiri, Seyed Adel Moallem
المصدر: Journal of Research in Medical Sciences, Vol 17, Iss 9, Pp 876-881 (2012)
بيانات النشر: Wolters Kluwer Medknow Publications, 2012.
سنة النشر: 2012
المجموعة: LCC:Medicine
مصطلحات موضوعية: Anti-epileptic drugs, epilepsy, pregnancy, teratogen, Medicine
الوصف: Approximately 1% of all pregnancies are in woman with epilepsy. Although, the majority of children born to women with epilepsy are normal, they are at increased risk for malformations. Notably, the teratogenicity of antiepileptic drugs is a well-defined subject. The incidence of major malformations in offspring of mothers with epilepsy who were treated with AEDs is higher than women with untreated epilepsy and in the general population. These malformations include spina bifida, cleft palate, limb reduction defects, cardiac abnormalities, hypospadias, and gastrointestinal atresia. The exact mechanism by which the AEDs mediate abnormalities in the fetus is uncertain. However, there are several hypotheses to explain them. Some of the most important include folate-related actions, ischemia, reactive intermediates (e.g., free radicals), and genetic susceptibility. Thus, understanding the mechanisms of AED-related abnormalities is of vital importance for the care of epileptic women and their offspring.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1735-1995
1735-7136
العلاقة: http://www.jmsjournal.net/article.asp?issn=1735-1995;year=2012;volume=17;issue=9;spage=876;epage=881;aulast=EtemadTest; https://doaj.org/toc/1735-1995Test; https://doaj.org/toc/1735-7136Test
الوصول الحر: https://doaj.org/article/d8540ce2952c466e9bbe0b4f20073b0bTest
رقم الانضمام: edsdoj.8540ce2952c466e9bbe0b4f20073b0b
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:17351995
17357136