Effectiveness of radiotherapy to prevent recurrence of heterotopic ossification in patients with spinal cord injury and traumatic head injury: A retrospective case-controlled study
| العنوان: | Effectiveness of radiotherapy to prevent recurrence of heterotopic ossification in patients with spinal cord injury and traumatic head injury: A retrospective case-controlled study |
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| المؤلفون: | Guillaume Genet, François Genêt, Philippe Denormandie, Isabelle Bonan, Thibaud Honore, Amandine Grelier, Marjorie Salga, Alain Labib |
| المساهمون: | Handicap neuromusculaire : Physiopathologie, Biothérapie et Pharmacologies appliquées (END-ICAP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM), Hôpital Raymond Poincaré [AP-HP], Hôpital René HUGUENIN (Saint-Cloud), Empenn, Institut National de la Santé et de la Recherche Médicale (INSERM)-Inria Rennes – Bretagne Atlantique, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-SIGNAUX ET IMAGES NUMÉRIQUES, ROBOTIQUE (IRISA-D5), Institut de Recherche en Informatique et Systèmes Aléatoires (IRISA), Université de Bretagne Sud (UBS)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National de Recherche en Informatique et en Automatique (Inria)-École normale supérieure - Rennes (ENS Rennes)-Centre National de la Recherche Scientifique (CNRS)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-CentraleSupélec-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Université de Bretagne Sud (UBS)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Institut de Recherche en Informatique et Systèmes Aléatoires (IRISA), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-École normale supérieure - Rennes (ENS Rennes)-Centre National de la Recherche Scientifique (CNRS)-Université de Rennes 1 (UR1), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), Neuroimagerie: méthodes et applications (Empenn), Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université de Bretagne Sud (UBS)-École normale supérieure - Rennes (ENS Rennes)-Institut National de Recherche en Informatique et en Automatique (Inria)-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université de Bretagne Sud (UBS)-École normale supérieure - Rennes (ENS Rennes)-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique (IMT Atlantique), HAL UVSQ, Équipe |
| المصدر: | Journal of Rehabilitation Medicine Journal of Rehabilitation Medicine, Foundation for Rehabilitation Information, 2020, 52 (5), pp.1-6. ⟨10.2340/16501977-2692⟩ Journal of Rehabilitation Medicine, Vol 52, Iss 5, p jrm00066 (2020) Journal of Rehabilitation Medicine, 2020, 52 (5), pp.1-6. ⟨10.2340/16501977-2692⟩ |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Adult, Male, 030506 rehabilitation, medicine.medical_specialty, Traumatic brain injury, medicine.medical_treatment, [SDV]Life Sciences [q-bio], Physical Therapy, Sports Therapy and Rehabilitation, Sepsis, 03 medical and health sciences, Young Adult, Postoperative Complications, Recurrence, medicine, Humans, Spinal cord injury, radiotherapy, Spinal Cord Injuries, Retrospective Studies, business.industry, traumatic brain injury, Ossification, Heterotopic, Rehabilitation, Head injury, lcsh:RM1-950, Case-control study, General Medicine, Odds ratio, medicine.disease, spinal cord injury, 3. Good health, Surgery, [SDV] Life Sciences [q-bio], Radiation therapy, lcsh:Therapeutics. Pharmacology, heterotopic ossification, Case-Control Studies, excision, Heterotopic ossification, Female, 0305 other medical science, business |
| الوصف: | Objective To evaluate recurrence and early postoperative complications (sepsis) following surgical excision combined with radiotherapy for troublesome hip heterotopic ossification in patients with spinal cord injury and traumatic brain injury. Design Retrospective case-control study. Setting Data relating to patients with spinal cord injury or traumatic brain injury who underwent surgical excision of hip heterotopic ossification were retrieved from the BANKHO database. Case patients underwent excision + radiotherapy and controls underwent excision only. Control patients were matched to case patients according to sex and age (± 4 years). Participants Data from 19 case patients and 76 controls were analysed. Interventions Not applicable. Main outcome measure The primary end-point was recurrence of heterotopic ossification. Secondary end-points were postoperative complications and, more specifically, sepsis that required surgical revision. Results There was no difference between the odds ratios (OR) for recurrence for each group (OR case group = 0.63, OR spinal cord injury subgroup = 0.45 and OR head injury subgroup = 1.04). The rate of sepsis requiring surgical revision was significantly higher in the case group (p Conclusion Based on the results of this case-control study, we suggest that radiotherapy should not be combined with surgery in patients with troublesome hip heterotopic ossification undergoing excision. Radiotherapy does not appear to prevent recurrence and, moreover, it is associated with an increased risk of postoperative sepsis. |
| وصف الملف: | application/pdf |
| تدمد: | 1651-2081 1650-1977 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3357b3cd2cb905212e05c7f5fac6cdb1Test https://pubmed.ncbi.nlm.nih.gov/32421202Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....3357b3cd2cb905212e05c7f5fac6cdb1 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16512081 16501977 |
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