Autocatalytic Degradation and Stability of Obidoxime
| العنوان: | Autocatalytic Degradation and Stability of Obidoxime |
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| المؤلفون: | Shai Rubnov, Dan Henry Levy, Igor Shats, Hava Schneider, Shai Amisar |
| المصدر: | Journal of Pharmacy and Pharmacology. 51:9-14 |
| بيانات النشر: | Oxford University Press (OUP), 1999. |
| سنة النشر: | 1999 |
| مصطلحات موضوعية: | Pharmacology, Obidoxime, Cholinesterase Reactivators, Reaction mechanism, Obidoxime Chloride, Time Factors, Chemistry, Stereochemistry, Hydrolysis, Temperature, Formaldehyde, Pharmaceutical Science, Hydrogen-Ion Concentration, Autocatalysis, chemistry.chemical_compound, Drug Stability, medicine, Degradation (geology), Chemical stability, Chromatography, High Pressure Liquid, Chemical decomposition, medicine.drug, Nuclear chemistry |
| الوصف: | The degradation of obidoxime chloride (toxogonin), a reactivator of inhibited cholinesterase in organophosphorus poisoning, in concentrated (250 mg mL−1) acidic solutions was studied by HPLC at several temperatures to determine the degradation mechanism. The degradation had an autocatalytic profile, which was found to result from the formation of formaldehyde during the degradation process. The activation energy of the hydrolysis was 26.2 kcal mol−1. The shelf-life (t90, the time by which 10% of the drug has degraded) at 25°C was calculated by several methods and found to be more than 37 years. Autocatalysis, a mechanism found only rarely in the degradation of pharmaceuticals, has not been reported in previous studies of obidoxime hydrolysis. |
| تدمد: | 2042-7158 0022-3573 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e315786390c3c6cc31d0c70349cb991Test https://doi.org/10.1211/0022357991772024Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....8e315786390c3c6cc31d0c70349cb991 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20427158 00223573 |
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