التفاصيل البيبلوغرافية
| العنوان: |
Inhibition of human ether-à-go-go-related gene K+ currents expressed in HEK293 cells by three gingerol components from ginger. |
| المؤلفون: |
Liu, Miaomaio1 (AUTHOR), Yang, Yakun1 (AUTHOR), Zhang, Muqing1 (AUTHOR), Xue, Yucong1 (AUTHOR), Zheng, Bin1 (AUTHOR), Zhang, Yuanyuan1 (AUTHOR), Liu, Yu1 (AUTHOR), Chu, Xi2 (AUTHOR), Sun, Zhenqing3 (AUTHOR), Han, Xue4,5 (AUTHOR) hanxuecc@126.com |
| المصدر: |
Journal of Pharmacy & Pharmacology. Aug2022, Vol. 74 Issue 8, p1133-1139. 7p. |
| مصطلحات موضوعية: |
*GINGER, *HUMAN genes, *BIOACTIVE compounds |
| مستخلص: |
Objectives Gingerols are bioactive compounds derived from ginger, our experiment investigates the effects of 6-, 8- and 10-Gin on the human ether-à-go-go-related gene (hERG) K+ channels by using patch clamp technology. Key findings hERG K+ currents were suppressed by 6-, 8- and 10-Gin in a concentration-dependent manner. The IC50 values of 6-, 8- and 10-Gin were 41.5, 16.1 and 86.5 μM for the hERG K+ currents, respectively. The maximum inhibitory effects caused by 6-, 8- and 10-Gin were 44.3% ± 2.0%, 88.6% ± 1.3% and 63.1% ± 1.1%, respectively, and the effects were almost completely reversible. Conclusion These findings suggest that 8-Gin is the most potent hERG K+ channel inhibitor among gingerol components and may offer a new approach for understanding and treating cancer. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
Academic Search Index |
