التفاصيل البيبلوغرافية
| العنوان: |
Association of CLDN18 Protein Expression with Clinicopathological Features and Prognosis in Advanced Gastric and Gastroesophageal Junction Adenocarcinomas. |
| المؤلفون: |
Pellino, Antonio, Brignola, Stefano, Riello, Erika, Niero, Monia, Murgioni, Sabina, Guido, Maria, Nappo, Floriana, Businello, Gianluca, Sbaraglia, Marta, Bergamo, Francesca, Spolverato, Gaya, Pucciarelli, Salvatore, Merigliano, Stefano, Pilati, Pierluigi, Cavallin, Francesco, Realdon, Stefano, Farinati, Fabio, Dei Tos, Angelo Paolo, Zagonel, Vittorina, Lonardi, Sara |
| المصدر: |
Journal of Personalized Medicine; Nov2021, Vol. 11 Issue 11, p1095-1095, 1p |
| مصطلحات موضوعية: |
ESOPHAGOGASTRIC junction, PROTEIN expression, OVERALL survival, SURVIVAL rate, BREAST cancer prognosis, ADENOCARCINOMA, MONOCLONAL antibodies |
| مستخلص: |
Simple Summary: Claudin-18 is a tight junction protein expressed in various cancer types including gastric and gastroesophageal junction cancer. The claudin-18.2 isoform represents a promising target for novel experimental drugs such as zolbetuximab (IMAB362), currently under investigation in several clinical trials of advanced gastrointestinal tumors. In this study, we aim to evaluate the immunohistochemical profile of CLDN18 in a real-world and mono-institutional series of gastric and gastroesophageal carcinomas. The association of CLDN18 expression with clinicopathological features and survival outcomes was investigated. The tight junction protein claudin-18 (CLDN18), is often expressed in various cancer types including gastric (GC) and gastroesophageal adenocarcinomas (GECs). In the last years, the isoform CLDN18.2 emerged as a potential drug target in metastatic GCs, leading to the development of monoclonal antibodies against this protein. CLDN18.2 is the dominant isoform of CLDN18 in normal gastric and gastric cancer tissues. In this work, we evaluated the immunohistochemical (IHC) profile of CLDN18 and its correlation with clinical and histopathological features including p53, E-cadherin, MSH2, MSH6, MLH1, PMS2, HER2, EBER and PD-L1 combined positive score, in a large real-world and mono-institutional series of advanced GCs (n = 280) and GECs (n = 70). The association of IHC results with survival outcomes was also investigated. High membranous CLDN18 expression (2+ and 3+ intensity ≥75%) was found in 117/350 (33.4%) samples analyzed. CLDN18 expression correlated with age <70 (p = 0.0035), positive EBV status (p = 0.002), high stage (III, IV) at diagnosis (p = 0.003), peritoneal involvement (p < 0.001) and lower incidence of liver metastases (p = 0.013). CLDN18 did not correlate with overall survival. The predictive value of response of CLDN18 to targeted agents is under investigation in several clinical trials and further studies will be needed to select patients who could benefit from these therapies. [ABSTRACT FROM AUTHOR] |
|
Copyright of Journal of Personalized Medicine is the property of MDPI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
Full Text Finder