Diabetic Retinopathy and Skin Tissue Advanced Glycation End Products Are Biomarkers of Cardiovascular Events in Type 2 Diabetic Patients
| العنوان: | Diabetic Retinopathy and Skin Tissue Advanced Glycation End Products Are Biomarkers of Cardiovascular Events in Type 2 Diabetic Patients |
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| المؤلفون: | Alejandra Planas, Olga Simó-Servat, Cristina Hernández, Ángel Ortiz-Zúñiga, Joan Ramón Marsal, José R. Herance, Ignacio Ferreira-González, Rafael Simó |
| المساهمون: | Institut Català de la Salut, [Planas A, Simó-Servat O, Hernández C, Ortiz-Zúñiga Á, Simó R] Unitat de Recerca en Diabetis i Metabolisme, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Spanish Institute of Health (ISCIII), 28029 Madrid, Spain. [Marsal JR, Ferreira-González I] Servei de Cardiologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. CIBER en Epidemiología y Salud Pública (CIBERESP), Spanish Institute of Health (ISCIII), 28029 Madrid, Spain. [Hernández C] Grup de Recerca en Imatge Molecular Mèdica, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Servei de Medicina Nuclear, Vall d’Hebron Hospital Universitari, Barcelona, Spain. CIBBIM-Nanomedicina, Universitat Autònoma de Barcelona, Bellaterra, Spain. CIBERBBN, Spanish Institute of Health (ISCIII), 28029 Madrid, Spain, Vall d'Hebron Barcelona Hospital Campus |
| المصدر: | Scientia Journal of Personalized Medicine Journal of Personalized Medicine, Vol 11, Iss 1344, p 1344 (2021) Journal of Personalized Medicine; Volume 11; Issue 12; Pages: 1344 |
| بيانات النشر: | MDPI AG, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | enfermedades del sistema endocrino::diabetes mellitus::complicaciones de la diabetes::angiopatías diabéticas::retinopatía diabética [ENFERMEDADES], Endocrine System Diseases::Diabetes Mellitus::Diabetes Complications::Diabetic Angiopathies::Diabetic Retinopathy [DISEASES], Cardiovascular Diseases [DISEASES], Otros calificadores::/diagnóstico [Otros calificadores], Medicine (miscellaneous), cardiovascular disease biomarkers, Article, aminoácidos, péptidos y proteínas::proteínas::productos finales de la degradación proteica::productos finales de la glicación avanzada [COMPUESTOS QUÍMICOS Y DROGAS], diabetic retinopathy, cardiovascular disease, advanced glycation end-products, type 2 diabetes, diabetic complications, Amino Acids, Peptides, and Proteins::Proteins::Protein Degradation End Products::Glycation End Products, Advanced [CHEMICALS AND DRUGS], Retinopatia diabètica, Other subheadings::/diagnosis [Other subheadings], Medicine, Cor - Malalties - Factors de risc, Glicosilació, enfermedades cardiovasculares [ENFERMEDADES] |
| الوصف: | Cardiovascular disease biomarkers; Diabetic complications; Type 2 diabetes Biomarcadores de enfermedades cardiovasculares; Complicaciones de la diabetes; Diabetes tipo 2 Biomarcadors de malalties cardiovasculars; Complicacions de la diabetis; Diabetis tipus 2 Risk of cardiovascular events is not homogeneous in subjects with type 2 diabetes; therefore, its early identification remains a challenge to be met. The aim of this study is to evaluate whether the presence of diabetic retinopathy and accumulation of advanced glycation end-products in subcutaneous tissue can help identify patients at high risk of cardiovascular events. For this purpose, we conducted a prospective study (mean follow-up: 4.35 years) comprising 200 subjects with type 2 diabetes with no history of clinical cardiovascular disease and 60 non-diabetic controls matched by age and sex. The primary outcome was defined as the composite of myocardial infarction, coronary revascularization, stroke, lower limb amputation or cardiovascular death. The Cox proportional hazard multiple regression analysis was used to determine the independent predictors of cardiovascular events. The patients with type 2 diabetes had significantly more cardiovascular events than the non-diabetic subjects. Apart from the classic factors such as age, sex and coronary artery calcium score, we observed that the diabetic retinopathy and advanced glycation end-products in subcutaneous tissue were independent predictors of cardiovascular events. We conclude that the diabetic retinopathy and advanced glycation end-products in subcutaneous tissue could be useful biomarkers for selecting type 2 diabetic patients in whom the screening for cardiovascular disease should be prioritized, thereby creating more personalized and cost-effective medicine. This research was funded by grants from the Spanish Institute of Health (ISCIII) in the setting of Integrative Excellence Projects (PIE 2013/27) and the European Foundation for the Study of Diabetes (EFSD Pilot Research Grant Programme for Innovative Measurement of Diabetes Outcomes 2017). The study funders were not involved in the design of the study. |
| وصف الملف: | application/pdf |
| تدمد: | 2075-4426 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4675bccd76cef654e9c448f7fc4e7f7Test https://doi.org/10.3390/jpm11121344Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....b4675bccd76cef654e9c448f7fc4e7f7 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20754426 |
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