دورية
Clofarabine for Lymphodepletion Before CAR-T-Cell Infusion: A Brief Case Report
| العنوان: | Clofarabine for Lymphodepletion Before CAR-T-Cell Infusion: A Brief Case Report |
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| المؤلفون: | Foti, Alycia, Stein, Dylan, Seidel, Drew, Levine, Jennifer, Hijiya, Nobuko, Williams, Olatundun, George, Diane, Bhatia, Monica, Satwani, Prakash |
| المصدر: | Journal of Pediatric Hematology / Oncology; May 2023, Vol. 45 Issue: 4 pe551-e554, 4p |
| مستخلص: | Given the shortage of fludarabine, alternative preparative lymphodepleting regimens for CAR-T-cell therapy need to be identified. We present a case of relapsed/refractory B-cell acute lymphoblastic leukemia requiring multiple lines of salvage therapy with persistent extensive disease, who underwent lymphodepletion with clofarabine and cyclophosphamide before tisagenlecleucel CD19+ CAR-T-cell infusion with eventual remission. We offer evidence of clofarabine’s activity against B-cell acute lymphoblastic leukemia in combination with tisagenlecleucel therapy. In this patient, clofarabine did not decrease CAR-T-cell effectiveness, supported by presence of cytokine release syndrome and ultimate minimal residual disease negativity both on flow cytometry and next-generation sequencing. |
| قاعدة البيانات: | Supplemental Index |
| تدمد: | 10774114 15363678 |
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| DOI: | 10.1097/MPH.0000000000002668 |