Clinical Course of Pediatric and Adolescent Graves' Disease Treated with Radioactive Iodine
| العنوان: | Clinical Course of Pediatric and Adolescent Graves' Disease Treated with Radioactive Iodine |
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| المؤلفون: | Sonia Salisbury, Teresa E. Pinto, Elizabeth A. Cummings, David Barnes |
| المصدر: | Journal of Pediatric Endocrinology and Metabolism. 20 |
| بيانات النشر: | Walter de Gruyter GmbH, 2007. |
| سنة النشر: | 2007 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Pediatrics, Adolescent, Endocrinology, Diabetes and Metabolism, Graves' disease, Population, Disease, Iodine Radioisotopes, Endocrinology, hemic and lymphatic diseases, Humans, Medicine, Dosing, Child, education, Retrospective Studies, education.field_of_study, business.industry, Thyroid, Clinical course, medicine.disease, Graves Disease, Surgery, Pediatric endocrinology clinic, Treatment Outcome, medicine.anatomical_structure, Child, Preschool, Pediatrics, Perinatology and Child Health, Female, Radioactive iodine, business |
| الوصف: | The use of radioactive iodine (RAI) therapy in children and adolescents with Graves' disease is increasing; however, few data exist to guide dosing in this population. We aimed to determine the clinical course, failure rate and factors associated with failure of RAI for pediatric Graves' disease. A retrospective chart review from a tertiary care pediatric endocrinology clinic (1990-2003) identified 22 patients (12.7 +/- 4.0 years at diagnosis) with Graves' disease treated with RAI after initial pharmacological therapy. Patients received a calculated dose of RAI (0.1 mCi/g thyroid tissue, adjusted for 6-h radio-iodine uptake). Twenty-seven percent (95% CI 11-50%) remained hyperthyroid and required a second dose. If the first RAI was successful, the average time to hypothyroidism was 2.96 +/- 1.05 months. There were no statistically significant differences between those successfully treated with one dose and those requiring re-treatment. This high failure rate indicates a need to examine dosing of RAI in this age group. |
| تدمد: | 2191-0251 0334-018X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9ce4d88752e9b5f6af03a715e3dfcd8Test https://doi.org/10.1515/jpem.2007.20.9.973Test |
| رقم الانضمام: | edsair.doi.dedup.....a9ce4d88752e9b5f6af03a715e3dfcd8 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 21910251 0334018X |
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