التفاصيل البيبلوغرافية
| العنوان: |
Characterisation of parathyroid hormone concentration in extremely preterm or very low birthweight infants in routine clinical screening for metabolic bone disease: A service evaluation cohort study. |
| المؤلفون: |
Levene, Ilana, Dhami, Amraj, Moreno, Mar, Shine, Brian, Chinoy, Amish, Padidela, Raja, Molnar, Zoltan |
| المصدر: |
Journal of Paediatrics & Child Health; Oct2023, Vol. 59 Issue 10, p1140-1145, 6p |
| مصطلحات موضوعية: |
METABOLIC bone disorders, HYPOPARATHYROIDISM, MEDICAL screening, INFANTS, PARATHYROID hormone, BIRTH weight |
| مصطلحات جغرافية: |
UNITED Kingdom |
| مستخلص: |
Aim: To characterise parathyroid hormone (PTH) concentrations in infants at high risk for metabolic bone disease, in order to assist clinical decisions around the use of PTH for screening. Methods: Infants born under 28 weeks' postmenstrual age or with birthweight under 1.5 kg in a tertiary neonatal unit in the UK were included. Clinical guidance was to assess PTH concentration in the first 3 weeks after birth. Clinical information was extracted from prospective records. Results: Sixty‐four infants had mean birth gestation of 26 weeks and birthweight of 882 g. Median PTH (sent on median day 18 of life) was 9.2 pmol/L (interquartile range 5.3–17 pmol/L). Sixty‐seven per cent of infants had a PTH greater than 7 pmol/L. For 22% of the infants, raised PTH was not accompanied by abnormal phosphate or alkaline phosphatase. Eighty‐nine per cent of infants tested were insufficient or deficient for 25‐hydroxyvitamin D. Conclusions: Universal screening highlights the high frequency of high PTH in this high‐risk population, implying a need for calcium supplementation. A considerable number of infants would not be identified as showing potential signs of metabolic bone disease if the assessment excludes the use of PTH. The high level of 25‐hydroxyvitamin D deficiency may be a confounder. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
