المؤلفون: Stefano Palomba, Angela Falbo, Giovanni Battista La Sala, Francesco Capodanno, Maria Fini, A. Nicoli

المصدر: Journal of Ovarian Research

مصطلحات موضوعية: Morphology, medicine.medical_specialty, Zygote, medicine.medical_treatment, Review, Biology, ICSI, Intracytoplasmic sperm injection, Andrology, Obstetrics and Gynaecology, ARTs, Embryo, IVF, Oncology, Obstetrics and Gynecology, medicine, Blastocyst, Clinical efficacy, Gynecology, Pregnancy, In vitro fertilisation, medicine.disease, medicine.anatomical_structure, Embryo quality

الوصف: The current systematic review was aimed to assess the effectiveness of the zygote morphology evaluation in fresh in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) cycles. All available studies reporting on zygote morphology and clinical and/or biological outcomes were analyzed. Forty studies were included in the final analysis. Fourteen different zygote scoring systems were employed. Zygote morphology correlated significantly with embryo quality and cleavage, blastocyst stage, embryonic chromosome status, in a high proportion of the studies which assessed the specific outcome [15/25 (60%), 15/20 (75%), 7/8 (87.5%), 6/6 (100%), respectively]. On the other hand, only a reduced proportion of papers showed a statistically significant relationship between implantation, pregnancy and delivery/live-birth rates and zygote morphology score [12/23 (52.2%), 12/25 (48%), 1/4 (25%), respectively]. In conclusion, our findings demonstrate the lack of conclusive data on the clinical efficacy of the zygote morphology evaluation in fresh IVF/ICSI cycles, even if biological results showing a good relationship with embryo viability suggest a role in cycles in which the transfer/freezing is performed at day 1.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4cbad652160876579ab119c939e63aeTest
https://doi.org/10.1186/1757-2215-6-64Test

المؤلفون: Daria Morini, Barbara Valli, Francesco Capodanno, Maria Teresa Villani, Ilaria Rondini, Giovanni Battista La Sala, Stefano Palomba, Alessia Nicoli, Leonardo De Pascalis

المساهمون: Nicoli A., Capodanno F., Rondini I., Valli B., Villani M.T., Morini D., De Pascalis L., Palomba S., La Sala G.B.

المصدر: Journal of Ovarian Research, Vol 6, Iss 1, p 1 (2013)
Journal of Ovarian Research

مصطلحات موضوعية: medicine.medical_specialty, animal structures, medicine.medical_treatment, Pronuclear morphology, Review, Embryo morphology, ICSI, IVF, Live-birth, Pregnancy, Oncology, Obstetrics and Gynecology, lcsh:Gynecology and obstetrics, Intracytoplasmic sperm injection, Andrology, Obstetrics and Gynaecology, medicine, reproductive and urinary physiology, lcsh:RG1-991, Gynecology, Zygote, In vitro fertilisation, business.industry, urogenital system, Embryogenesis, Embryo, medicine.disease, Pregnancy rate, embryonic structures, business, Embryo quality

الوصف: Background The assessment of the embryo quality is crucial to maintain an high pregnancy rate and to reduce the risk of multiple pregnancy. The evaluation of the pronuclear and nucleolar characteristics of human zygote have been proposed as an indicator of embryo development and chromosomal complement. The aim of the current study was to assess the role of pronuclear morphology evaluation in vitro fertilization (IVF) / intracytoplasmic sperm injection (ICSI) cycles. Methods Retrospective clinical analysis on 755 non-elective transfers of only one embryo (ET). Embryo assessment was performed in days 1 and 2. Clinical and biological data were recorded and analyzed according to embryo and/or pronuclear morphology. Results Both pronuclear and embryo morphology were significantly related to clinical pregnancy and live-birth rates. No significant difference in clinical pregnancy and live-birth rates was detected when the pronuclear and embryo morphology assessments were combined. Embryo morphology and maternal age were the only independent predictors of favorable outcome by logistic regression analysis. Conclusions Pronuclear evaluation is effective to select the best zygotes if ET is performed at day 1, whereas it did not improve the clinical outcomes when combined with embryo morphology evaluation in day 2.

وصف الملف: ELETTRONICO

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc1532107e2da383e6f4d0f7b97665eaTest
http://www.ovarianresearch.com/content/6/1/1Test

المؤلفون: Chiara Ventura, Pierandrea De Iaco, Gino Ciarlini, Bruno Lenzi, Debora Pirillo, Rossana De Palma, Alessandro Ventura, Maurizio Leoni, Andrea Amadori, G Comerci, Debora Formisano, Giovanni Battista La Sala, F. Rosati, Ruby Martinello, Laura Maria Beatrice Belotti, Vincenzo Dario Mandato, Martino Abrate

المساهمون: Mandato, Vincenzo Dario, Abrate, Martino, De Iaco, Pierandrea, Pirillo, Debora, Ciarlini, Gino, Leoni, Maurizio, Comerci, Giuseppe, Ventura, Alessandro, Lenzi, Bruno, Amadori, Andrea, Rosati, Federica, Martinello, Ruby, De Palma, Rossana, Ventura, Chiara, Belotti, Laura Maria Beatrice, Formisano, Debora, La Sala, Giovanni Battista

المصدر: Journal of Ovarian Research

مصطلحات موضوعية: Clinical audit, medicine.medical_specialty, media_common.quotation_subject, Centralized care, Epithelial ovarian cancer, Guide line, Quality of care, Oncology, Obstetrics and Gynecology, Reproductive medicine, Disease, Audit, Obstetrics and gynaecology, Obstetrics and Gynaecology, medicine, Quality (business), media_common, Gynecology, Clinical governance, business.industry, Research, General surgery, Medical record, business

الوصف: Background: Epithelial ovarian cancer (EOC) is the most lethal gynecological cancer. Several hospitals throughout the region provide primary treatment for these patients and it is well know that treatment quality is correlated to the hospital that delivers. The aim of this study was to investigate the management and treatment of EOC in a Region of the North Italy (Emilia-Romagna, Italy). Methods. A multidisciplinary group made up of 11 physicians and 3 biostatisticians was formed in 2009 to perform clinical audits in order to identify quality indicators and to develop Region-wide workup in accordance with the principles of evidence-based medicine (EBM). The rationale was that, by setting up an oncogynecology network so as to achieve the best clinical practice, critical points would decrease or even be eliminated. Analysis of cases was based on the review of the medical records. Results: 614 EOC patients treated between 2007 and 2008 were identified. We found only 2 high-volume hospitals (≥ 21 patients/year), 3 medium-volume hospitals (11-20 operated patients/year), and 7 low-volume hospitals (≤ 10 operated patients /year). Only 222 patients (76.3%) had a histological diagnosis, FIGO surgical staging was reported only in 206 patients (70.9%) but not all standard surgical procedures were always performed, residual disease were not reported in all patients. No standard number of neoadjuvant chemotherapy cycles was observed. Conclusions: The differences in terms of treatments provided led the multidisciplinary group to identify reference centers, to promote centralization, to ensure uniform and adequate treatment to patients treated in regional centers and to promote a new audit involving all regional hospitals to a complete review of the all the EOC patients. © 2013 Mandato et al.; licensee BioMed Central Ltd.

وصف الملف: ELETTRONICO

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b2644432f5c47bc002d224c094093ccTest