Pronuclear morphology evaluation in in vitro fertilization (IVF) / intracytoplasmic sperm injection (ICSI) cycles: a retrospective clinical review
| العنوان: | Pronuclear morphology evaluation in in vitro fertilization (IVF) / intracytoplasmic sperm injection (ICSI) cycles: a retrospective clinical review |
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| المؤلفون: | Daria Morini, Barbara Valli, Francesco Capodanno, Maria Teresa Villani, Ilaria Rondini, Giovanni Battista La Sala, Stefano Palomba, Alessia Nicoli, Leonardo De Pascalis |
| المساهمون: | Nicoli A., Capodanno F., Rondini I., Valli B., Villani M.T., Morini D., De Pascalis L., Palomba S., La Sala G.B. |
| المصدر: | Journal of Ovarian Research, Vol 6, Iss 1, p 1 (2013) Journal of Ovarian Research |
| بيانات النشر: | BMC, 2013. |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | medicine.medical_specialty, animal structures, medicine.medical_treatment, Pronuclear morphology, Review, Embryo morphology, ICSI, IVF, Live-birth, Pregnancy, Oncology, Obstetrics and Gynecology, lcsh:Gynecology and obstetrics, Intracytoplasmic sperm injection, Andrology, Obstetrics and Gynaecology, medicine, reproductive and urinary physiology, lcsh:RG1-991, Gynecology, Zygote, In vitro fertilisation, business.industry, urogenital system, Embryogenesis, Embryo, medicine.disease, Pregnancy rate, embryonic structures, business, Embryo quality |
| الوصف: | Background The assessment of the embryo quality is crucial to maintain an high pregnancy rate and to reduce the risk of multiple pregnancy. The evaluation of the pronuclear and nucleolar characteristics of human zygote have been proposed as an indicator of embryo development and chromosomal complement. The aim of the current study was to assess the role of pronuclear morphology evaluation in vitro fertilization (IVF) / intracytoplasmic sperm injection (ICSI) cycles. Methods Retrospective clinical analysis on 755 non-elective transfers of only one embryo (ET). Embryo assessment was performed in days 1 and 2. Clinical and biological data were recorded and analyzed according to embryo and/or pronuclear morphology. Results Both pronuclear and embryo morphology were significantly related to clinical pregnancy and live-birth rates. No significant difference in clinical pregnancy and live-birth rates was detected when the pronuclear and embryo morphology assessments were combined. Embryo morphology and maternal age were the only independent predictors of favorable outcome by logistic regression analysis. Conclusions Pronuclear evaluation is effective to select the best zygotes if ET is performed at day 1, whereas it did not improve the clinical outcomes when combined with embryo morphology evaluation in day 2. |
| وصف الملف: | ELETTRONICO |
| اللغة: | English |
| تدمد: | 1757-2215 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc1532107e2da383e6f4d0f7b97665eaTest http://www.ovarianresearch.com/content/6/1/1Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....dc1532107e2da383e6f4d0f7b97665ea |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17572215 |
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