التفاصيل البيبلوغرافية
| العنوان: |
Stereocontrolled Synthesis of 1,3-Diols from Enones: Cooperative Lewis Base-Mediated Intramolecular Carbonyl Hydrosilylations. |
| المؤلفون: |
Medina, Casey1, Carter, Kyle P.1, Miller, Michael1, Clark, Timothy B.2, O'Neil, Gregory W.1 oneil@chem.wwu.edu |
| المصدر: |
Journal of Organic Chemistry. 9/20/2013, Vol. 78 Issue 18, p9093-9101. 9p. |
| مصطلحات موضوعية: |
*KETONES, *LEWIS bases, *CARBONYL compounds, *HYDROSILYLATION, *CHEMICAL reactions |
| مستخلص: |
A streamlined synthesis of β-hydroxy ketone substrates has been developed to further investigate a recently discovered cooperative Lewis base-mediated intramolecular carbonyl hydrosilylation reaction. The synthesis features an enone β-borylation/oxidation sequence that has proven to be quite general and high-yielding. This has allowed for additional investigations into the diastereoselectivity of the hydrosilylation reaction through the preparation of important polyketide fragments. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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