التفاصيل البيبلوغرافية
| العنوان: |
Nuclear β-catenin expression in basal cell adenomas of salivary gland. |
| المؤلفون: |
Kawahara, Akihiko, Harada, Hiroshi, Abe, Hideyuki, Yamaguchi, Tomohiko, Taira, Tomoki, Nakashima, Kazutaka, Mihashi, Hiroyuki, Akiba, Jun, Kage, Masayoshi |
| المصدر: |
Journal of Oral Pathology & Medicine; Jul2011, Vol. 40 Issue 6, p460-466, 7p, 2 Color Photographs, 3 Charts, 1 Graph |
| مصطلحات موضوعية: |
SALIVARY gland cancer, NUCLEAR proteins, BASAL cell carcinoma, GENE expression, IMMUNOHISTOCHEMISTRY, GENETIC mutation, NUCLEOTIDE sequence, EPITHELIAL cells |
| مستخلص: |
J Oral Pathol Med (2010) 40: 460–466 Background: Nuclear localization of β‐catenin is known in a wide variety of human neoplasms; however, there are few reports in basal cell adenoma of the salivary gland. Our objective was to confirm the nuclear localization of β‐catenin in basal cell adenoma and to examine whether nuclear β‐catenin expression could be a useful marker in the diagnosis of basal cell adenoma. Methods: To evaluate the nuclear localization of β‐catenin in basal cell adenomas, immunohistochemistry (IHC) and mutation analysis of CTNNB1 were performed in 22 and 21 cases, respectively. Mutation analysis of CTNNB1 in exon 3 was performed by DNA direct sequencing. In a comparative study, IHC for β‐catenin was also performed in 157 other salivary gland tumors. Results: Nuclear β‐catenin expression was examined in 22 basal cell adenomas; scores were 2+ in 18 cases (81.8%), 1+ in three cases (13.6%), and 0 in one case (4.5%). Expression was localized in the basaloid myoepithelial cells. CTNNB1 mutation analysis was performed in 21 basal cell adenomas; mutations, including I35T and T41P, were detected in 11/21 (52%) cases. In comparison with other salivary gland tumors, one of three basal cell adenocarcinomas showed nuclear β‐catenin expression, whereas there was no nuclear β‐catenin expression in 154 other salivary gland tumors. Conclusions: We demonstrated nuclear β‐catenin expression and activation of the CTNNB1 gene in basal cell adenoma. Although nuclear β‐catenin expression may be unable to distinguish basal cell adenoma from basal cell adenocarcinoma, it should be a helpful marker in the diagnosis of basal cell adenoma. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
