Association between Visual Acuity and Retinal Layer Metrics in Diabetics with and without Macular Edema
| العنوان: | Association between Visual Acuity and Retinal Layer Metrics in Diabetics with and without Macular Edema |
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| المؤلفون: | Norman P. Blair, Michael R. Tan, Justin Wanek, Xuejuan Jiang, Mahnaz Shahidi, J. Jason McAnany, LakshmiPriya Rangaraju, Jennifer I. Lim |
| المصدر: | Journal of Ophthalmology, Vol 2018 (2018) Journal of Ophthalmology |
| بيانات النشر: | Hindawi Limited, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | medicine.medical_specialty, Visual acuity, Article Subject, genetic structures, Nerve fiber layer, Outer plexiform layer, 01 natural sciences, 010309 optics, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, lcsh:Ophthalmology, Ophthalmology, 0103 physical sciences, medicine, Outer nuclear layer, Retinal pigment epithelium, business.industry, Retinal, Inner plexiform layer, Photoreceptor outer segment, eye diseases, medicine.anatomical_structure, chemistry, lcsh:RE1-994, 030221 ophthalmology & optometry, sense organs, medicine.symptom, business, Research Article |
| الوصف: | Purpose. Diabetes is known to cause alterations in retinal microvasculature and tissue that progressively lead to visual impairment. Optical coherence tomography (OCT) is useful for assessment of total retinal thickening due to diabetic macular edema (DME). In the current study, we determined associations between visual acuity (VA) and retinal layer thickness, reflectance, and interface disruption derived from enface OCT images in subjects with and without DME. Materials and Methods. Best corrected VA was measured and high-density OCT volume scans were acquired in 149 diabetic subjects. A previously established image segmentation method identified retinal layer interfaces and locations of visually indiscernible (disrupted) interfaces. Enface thickness maps and reflectance images of the nerve fiber layer (NFL), combined ganglion cell and inner plexiform layer (GCLIPL), inner nuclear layer (INL), outer plexiform layer (OPL), outer nuclear layer (ONL), photoreceptor outer segment layer (OSL), and retinal pigment epithelium (RPE) were generated in the central macular subfield. The associations among VA and retinal layer metrics were determined by multivariate linear regressions after adjusting for covariates (age, sex, race, HbA1c, diabetes type, and duration) and correcting for multiple comparisons. Results. In DME subjects, increased GCLIPL and OPL thickness and decreased OSL thickness were associated with reduced VA. Furthermore, increased NFL reflectance and decreased OSL reflectance were associated with reduced VA. Additionally, increased areas of INL and ONL interface disruptions were associated with reduced VA. In subjects without DME, increased INL thickness was associated with reduced VA, whereas in subjects without DME but with previous antivascular endothelium growth factor treatment, thickening of OPL was associated with reduced VA. Conclusions. Alterations in retinal layer thickness and reflectance metrics derived from enface OCT images were associated with reduced VA with and without presence of DME, suggestive of their potential for monitoring development, progression, and treatment of DME. |
| وصف الملف: | text/xhtml |
| اللغة: | English |
| تدمد: | 2090-0058 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d6d7ebdfda87379d93387103d1bb018Test https://doaj.org/article/291bde03123148e9814486c5130df86cTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....2d6d7ebdfda87379d93387103d1bb018 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20900058 |
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