التفاصيل البيبلوغرافية
| العنوان: |
Cancer Malignancy Is Enhanced by Glyceraldehyde-Derived Advanced Glycation End-Products. |
| المؤلفون: |
Takino, Jun-Ichi, Yamagishi, Sho-Ichi, Takeuchi, Masayoshi |
| المصدر: |
Journal of Oncology; 2010, p1-8, 8p, 1 Black and White Photograph, 4 Graphs |
| مصطلحات موضوعية: |
CANCER, CANCER cells, LUNG cancer, CELL proliferation, CANCER treatment |
| مستخلص: |
The receptor for advanced glycation end-products (RAGEs) is associated with the malignancy of cancer. A recent study has suggested that glyceraldehyde-derived AGEs (Glycer-AGEs) enhanced the malignancy of melanoma cells, but glucose-derived AGEs did not.However, the effects of Glycer-AGEs on other cancer cells remain poorly understood, and themolecularmechanisms behind the above-mentioned effect have not been clarified. The present paper aimed to examine the effect of Glycer-AGEs on cultured lung cancer A549 cells. RAGE was expressed in A549 cells. Glycer-AGEs significantly attenuated cell proliferation. Furthermore, Glycer-AGEs enhanced the migration capacity of the cells by activating Rac1 via ROS and also increased their invasion capacity. We demonstrated that Glycer-AGEs enhanced the migration and invasion of A549 cells rather than their proliferation. These results suggest that Glycer-AGEs play a critical role in the malignancy of cancer rather than its proliferation and are potential targets for therapeutic intervention. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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