التفاصيل البيبلوغرافية
| العنوان: |
Effects of obesity, metabolic syndrome, and non‐alcoholic or alcoholic elevated liver enzymes on incidence of diabetes following lifestyle intervention: A subanalysis of the J‐DOIT1. |
| المؤلفون: |
Sakane, Naoki, Kotani, Kazuhiko, Suganuma, Akiko, Takahashi, Kaoru, Sato, Juichi, Suzuki, Sadao, Izumi, Kazuo, Kato, Masayuki, Noda, Mitsuhiko, Nirengi, Shinsuke, Kuzuya, Hideshi |
| المصدر: |
Journal of Occupational Health; Jan2020, Vol. 62 Issue 1, p1-8, 8p |
| مصطلحات موضوعية: |
OBESITY, METABOLIC syndrome, LIVER enzymes, DIABETES, BODY mass index |
| مستخلص: |
Objectives: Using annual health check‐up data, the aim of this study was to identify target populations for lifestyle interventions to effectively prevent diabetes in a real‐world setting. Methods: The Japan Diabetes Outcome Intervention Trial‐1, a prospective, cluster‐randomized controlled trial, was launched to test if year‐long telephone‐delivered lifestyle support by health professionals can prevent the development of type 2 diabetes (T2D) in people with impaired fasting glucose (IFG) identified at health check‐ups. A total of 2607 participants aged 20‐65 years with IFG were randomized to an intervention arm (n = 1240) or a control arm (n = 1367). We performed subgroup analysis to examine the effects of the intervention on the incidence of T2D in participants with body mass index (BMI) ≥25, metabolic syndrome (MetS), and non‐alcoholic or alcoholic elevated liver enzymes at the baseline. Cox regression analysis adjusted for sex was used to calculate the hazard ratios (HRs). Results: In addition to IFG, the presence of BMI ≥25, MetS, and elevated liver enzymes increased the incidence of diabetes by two‐ or three‐fold. During a median follow‐up period of 4.9 years, only the non‐alcoholic elevated liver enzyme group showed a low incidence rate owing to lifestyle interventions (adjusted HR: 0.42, 95% confidence interval: 0.18‐0.98). Conclusion: The results suggest that people who have IFG and non‐alcoholic elevated liver enzymes are a good target population for lifestyle interventions to effectively reduce the incidence of diabetes in a real‐world setting. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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