التفاصيل البيبلوغرافية
| العنوان: |
Association between serum tumor necrosis factor-α and corticotropin-releasing hormone levels in women with preterm labor. |
| المؤلفون: |
Vitoratos, Nicolaos, Papadias, Konstantinos, Makrakis, Evangelos, Christodoulakos, George, Panoulis, Konstantinos, Creatsas, George |
| المصدر: |
Journal of Obstetrics & Gynaecology Research; Oct2006, Vol. 32 Issue 5, p497-501, 5p, 1 Chart, 4 Graphs |
| مصطلحات موضوعية: |
CORTICOTROPIN releasing hormone, TUMOR necrosis factors, CHILDBIRTH, PREMATURE labor, DURATION of pregnancy |
| مستخلص: |
Aim: To evaluate the association of serum corticotropin-releasing hormone (CRH) and tumor necrosis factor-α (TNF-α) in preterm labor. Methods: Forty-nine primigravidas with a singleton viable pregnancy between 28 and 34 weeks of gestation were studied. They were divided into two groups. Group A consisted of 30 pregnant women (mean gestational age: 30.6 week) who presented with preterm labor and group B consisted of 19 pregnant women (mean gestational age: 29.8 week) with normal pregnancies. Results: Women of group A had significantly higher serum CRH levels compared to those of group B ( P < 0.01). Similarly, serum TNF-α levels were significantly higher in women of group A when compared to women of group B (7.8 ± 3.72 pg/mL and 5.1 ± 3.72 pg/mL, respectively). Furthermore, a positive correlation was found between serum CRH and TNF-α levels in both groups, which was stronger in women of group A. Conclusions: Our findings suggest that the increased levels of TNF-α and CRH found in pregnant women presenting with preterm labor may be involved in the pathophysiological mechanism of the latter. Furthermore, a positive interaction may exist between TNF-α and placental CRH, which may lead to enhanced production of the second and, therefore, facilitate the onset of labor. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
