المؤلفون: Di Tommaso, Mariarosaria¹ (AUTHOR) mariarosaria.ditommaso@unifi.it, Seravalli, Viola¹ (AUTHOR), Arduino, Silvana² (AUTHOR), Bossotti, Carlotta² (AUTHOR), Sisti, Giovanni¹ (AUTHOR), Todros, Tullia² (AUTHOR)

المصدر: Journal of Obstetrics & Gynaecology. Aug2016, Vol. 36 Issue 6, p715-718. 4p.

مصطلحات موضوعية: *PREMATURE labor prevention, *CERVIX uteri, *TWINS, *CHILDBIRTH, *DELIVERY (Obstetrics)

مستخلص: A retrospective study was conducted to evaluate the effect of Arabin cervical pessary in twin pregnancies with cervical length (CL)  <25 mm between 21 and 31 weeks. Forty patients receiving pessary were matched with 40 controls without pessary. They were matched for gestational age (GA) at admission and CL. GA at delivery, delivery before 36, 34 and 32 weeks, latency between detection of short cervix and delivery, and duration of hospital admission were compared between groups. Women with the pessary delivered at higher GA compared to controls (35 vs. 33 weeks, p = 0.02). Cervical pessary significantly reduced the incidence of delivery  <36 and  < 34 weeks (p < 0.05), but not before 32 weeks. Interval between detection of short cervix and delivery was longer in the pessary group and duration of hospital admission was shorter (p = 0.03) compared to women without pessary. [ABSTRACT FROM AUTHOR]

المؤلفون: Bagga, R.¹ (AUTHOR), Takhtani, M.¹ (AUTHOR), Suri, V.¹ (AUTHOR), Adhikari, K.¹ (AUTHOR) drkp1981@gmail.com, Arora, S.² (AUTHOR), Bhardwaj, S.² (AUTHOR)

المصدر: Journal of Obstetrics & Gynaecology. Jul2010, Vol. 30 Issue 5, p451-455. 5p. 5 Charts, 1 Graph.

مصطلحات موضوعية: *PREMATURE labor, *PREGNANCY, *TRANSVAGINAL ultrasonography, *DELIVERY (Obstetrics), *CHILDBIRTH, *BIOMARKERS

مستخلص: The study group consisted of 100 women with a singleton pregnancy with pre-term labour between 26-36 weeks' gestation. Cervicovaginal secretions were collected for HCG assay and cervical length was measured by transvaginal sonography (TVS). These parameters were analysed to predict pre-term birth. The pre-term delivery rate was 55%; 24% delivered within 48 h and 11% within 7 days of admission. The sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of cervical length or=45 mIU/ml was the optimal cut-off, with a sensitivity, specificity, PPV and NPV for predicting delivery within 48 h and 7 days to be 95.8%, 73.7%, 53.5% and 98.2% and 85.7%, 80%, 69.8% and 91.2%, respectively. Combining either qualitative or quantitative HCG assay with cervical length significantly increased the sensitivity and NPV of cervical length alone for prediction of pre-term delivery both within 48 h and 7 days. It was concluded that increased cervicovaginal HCG and reduced cervical length predicted an increased risk of pre-term delivery in women with pre-term labour. Qualitative cervicovaginal HCG assay may be used as a bedside test to predict pre-term delivery within 48 h or within 7 days. [ABSTRACT FROM AUTHOR]

المؤلفون: Sawdy, R. J., Groom, Katie M., Bennett, P. R.

المصدر: Journal of Obstetrics & Gynaecology; Apr2004, Vol. 24 Issue 3, p226-229, 4p

مصطلحات موضوعية: SECOND trimester of pregnancy, PROSTAGLANDINS, PREMATURE labor, CHILDBIRTH, LABOR (Obstetrics), BIRTH weight, PLACEBOS

مستخلص: We report pregnancy outcome and fetal side effects in women at high risk of second trimester loss and early preterm delivery treated with nimesulide. This was a prospective observational study of 44 women treated with nimesulide from 17 to 32 weeks. All women underwent weekly ultrasound scans for AFI, Doppler studies of the ductus arteriosus and transvaginal assessment of cervical length. Outcome data were collected. Oligohydramnios occurred in 54% of cases; this returned to normal in all cases on discontinuation of treatment. There were no cases of constriction of the ductus arteriosus. Thirty-nine women took home a live baby. The mean gestation at delivery was 33 weeks and 1 day and the mean birth weight was 2105 g. Nimesulide appeared to have a significant benefit in women at high risk of preterm delivery with no long-term harmful effects on the fetus if monitored closely with an intensive ultrasound scanning regimen. Randomised placebo controlled trials are required to assess fully the benefit of COX-2 selective and specific prostaglandin synthesis inhibitors. [ABSTRACT FROM AUTHOR]

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