Objective To evaluate a community-wide campaign, Tu Salud iSi Cuenta! (TSSC), in improving eating behaviors and anthropometric outcomes in Hispanic border communities. Design A quasi-experimental study with matched intervention and comparison communities. Cross-sectional assessments with randomly sampled adults, examined by actual exposure and site (unexposed intervention, exposed intervention, and unexposed comparison). Setting and Participants Predominately Mexican Americans located in Brownsville, TX (intervention) and Laredo, TX (control). Intervention The TSSC campaign included television and radio segments, community health worker discussions, and newsletters delivered in Brownsville from 2005 to 2010. Main Outcome Measures Healthy and unhealthy eating indices and average hip and waist circumferences. Analysis Univariable and multivariable regression models. Results The sample (n = 799; 400 comparison and 399 intervention) was 98% of Mexican origin; 54% had completed grade 9 or higher. Exposure to any TSSC component was associated with a lower rate of unhealthy food consumption. Compared with the unexposed intervention group, the exposed intervention for the newsletter had a higher rate of healthy eating (adjusted rate ratio = 1.18; P Conclusions and Implications This study provides evidence for the use of community-wide campaigns for nutrition and obesity-related outcomes in Hispanic communities.