Meningiomas: knowledge base, treatment outcomes, and uncertainties. A RANO review
| العنوان: | Meningiomas: knowledge base, treatment outcomes, and uncertainties. A RANO review |
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| المؤلفون: | Damien C. Weber, Michael A. Vogelbaum, Marc C. Chamberlain, Igor J. Barani, Michael W. McDermott, Thomas Kaley, Jeffrey Raizer, David Schiff, Patrick Y. Wen, Leland Rogers |
| المصدر: | Journal of neurosurgery, vol 122, iss 1 |
| بيانات النشر: | Journal of Neurosurgery Publishing Group (JNSPG), 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | GTR = gross-total resection, RTOG = Radiation Therapy Oncology Group, medicine.medical_treatment, outcomes, meningioma, law.invention, SRS = stereotactic radiosurgery, surgery, Randomized controlled trial, law, Medicine, Cancer, PFS = progression-free survival, Brain Neoplasms, EORTC = European Organisation for Research and Treatment of Cancer, RANO = Response Assessment in Neuro-Oncology, Combined Modality Therapy, Treatment Outcome, EBRT = external beam radiation therapy, 6.1 Pharmaceuticals, oncology, MEN1 = multiple endocrine neoplasia Type 1, Meningioma, Recurrent Meningioma, CGE = cobalt gray equivalent, medicine.medical_specialty, Clinical Trials and Supportive Activities, Clinical Sciences, Brain tumor, Article, Disease-Free Survival, Radiosurgery, 7.3 Management and decision making, Rare Diseases, Clinical Research, otorhinolaryngologic diseases, Humans, Medical physics, NF2 = neurofibromatosis Type 2, radiotherapy, Neurology & Neurosurgery, business.industry, Neurosciences, Evaluation of treatments and therapeutic interventions, medicine.disease, Brain Disorders, Brain Cancer, Radiation therapy, Clinical trial, Management of diseases and conditions, business, STR = subtotal resection |
| الوصف: | Evolving interest in meningioma, the most common primary brain tumor, has refined contemporary management of these tumors. Problematic, however, is the paucity of prospective clinical trials that provide an evidence-based algorithm for managing meningioma. This review summarizes the published literature regarding the treatment of newly diagnosed and recurrent meningioma, with an emphasis on outcomes stratified by WHO tumor grade. Specifically, this review focuses on patient outcomes following treatment (either adjuvant or at recurrence) with surgery or radiation therapy inclusive of radiosurgery and fractionated radiation therapy. Phase II trials for patients with meningioma have recently completed accrual within the Radiation Therapy Oncology Group and the European Organisation for Research and Treatment of Cancer consortia, and Phase III studies are being developed. However, at present, there are no completed prospective, randomized trials assessing the role of either surgery or radiation therapy. Successful completion of future studies will require a multidisciplinary effort, dissemination of the current knowledge base, improved implementation of WHO grading criteria, standardization of response criteria and other outcome end points, and concerted efforts to address weaknesses in present treatment paradigms, particularly for patients with progressive or recurrent low-grade meningioma or with high-grade meningioma. In parallel efforts, Response Assessment in Neuro-Oncology (RANO) subcommittees are developing a paper on systemic therapies for meningioma and a separate article proposing standardized end point and response criteria for meningioma. |
| وصف الملف: | application/pdf |
| تدمد: | 1933-0693 0022-3085 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d50c24ff57638e53abe7764ae2e3796bTest https://doi.org/10.3171/2014.7.jns131644Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....d50c24ff57638e53abe7764ae2e3796b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19330693 00223085 |
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