Genetic Modulation of Soluble A Rescues Cognitive and Synaptic Impairment in a Mouse Model of Alzheimer's Disease
| العنوان: | Genetic Modulation of Soluble A Rescues Cognitive and Synaptic Impairment in a Mouse Model of Alzheimer's Disease |
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| المؤلفون: | Dorothy R. Schuler, Mathew A. Sherman, Ricky R. Savjani, Stephanie W. Fowler, Megan Larson, Sylvain Lesné, John R. Cirrito, Joanna L. Jankowsky, Angie C.A. Chiang |
| المصدر: | Journal of Neuroscience. 34:7871-7885 |
| بيانات النشر: | Society for Neuroscience, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Amyloid, Morris water navigation task, Mice, Transgenic, Plaque, Amyloid, Water maze, Amyloid beta-Protein Precursor, Mice, Alzheimer Disease, Amyloid precursor protein, medicine, Animals, Humans, Cognitive decline, Maze Learning, Alanine, biology, Chemistry, General Neuroscience, P3 peptide, Articles, Azepines, medicine.disease, Mice, Inbred C57BL, Disease Models, Animal, Doxycycline, Mutation, Synapses, Exploratory Behavior, biology.protein, Amyloid Precursor Protein Secretases, Alzheimer's disease, Cognition Disorders, Neuroscience, Amyloid precursor protein secretase |
| الوصف: | An unresolved debate in Alzheimer's disease (AD) is whether amyloid plaques are pathogenic, causing overt physical disruption of neural circuits, or protective, sequestering soluble forms of amyloid-β (Aβ) that initiate synaptic damage and cognitive decline. Few animal models of AD have been capable of isolating the relative contribution made by soluble and insoluble forms of Aβ to the behavioral symptoms and biochemical consequences of the disease. Here we use a controllable transgenic mouse model expressing a mutant form of amyloid precursor protein (APP) to distinguish the impact of soluble Aβ from that of deposited amyloid on cognitive function and synaptic structure. Rapid inhibition of transgenic APP modulated the production of Aβ without affecting pre-existing amyloid deposits and restored cognitive performance to the level of healthy controls in Morris water maze, radial arm water maze, and fear conditioning. Selective reduction of Aβ with a γ-secretase inhibitor provided similar improvement, suggesting that transgene suppression restored cognition, at least in part by lowering Aβ. Cognitive improvement coincided with reduced levels of synaptotoxic Aβ oligomers, greater synaptic density surrounding amyloid plaques, and increased expression of presynaptic and postsynaptic markers. Together these findings indicate that transient Aβ species underlie much of the cognitive and synaptic deficits observed in this model and demonstrate that significant functional and structural recovery can be attained without removing deposited amyloid. |
| تدمد: | 1529-2401 0270-6474 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2997839fbdee437e82f885d327b4c7e3Test https://doi.org/10.1523/jneurosci.0572-14.2014Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....2997839fbdee437e82f885d327b4c7e3 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15292401 02706474 |
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