Pathology-MRI Correlations in Diffuse Low-Grade Epilepsy Associated Tumors.

التفاصيل البيبلوغرافية
العنوان:	Pathology-MRI Correlations in Diffuse Low-Grade Epilepsy Associated Tumors.
المؤلفون:	Al-Hajri, Aliya, Al-Mughairi, Salim, Somani, Alyma, An, Shu, Liu, Joan, Miserocchi, Anna, McEvoy, Andrew W, Yousry, Tarek, Hoskote, Chandrashekar, Thom, Maria
المصدر:	Journal of Neuropathology and Experimental Neurology; December 2017, Vol. 76 Issue: 12 p1023-1033, 11p
مستخلص:	It is recognized that IDH mutation negative, low-grade epilepsy associated tumors (LEAT) can show diffuse growth patterns and lack the diagnostic hallmarks of either classical dysembryoplastic neuroepithelial tumors (DNT) or typical ganglioglioma. "Nonspecific or diffuse DNT" and more recently "polymorphous low-grade neuroepithelial tumor of the young" have been terms used for these entities. There are few reports on the MRI recognition of these diffuse glioneuronal tumors (dGNT), which is important in planning the extent of surgical resection. In 27 LEATs T1, T2, FLAIR, and postcontrast T1 MRI were evaluated and the pathology reviewed, including immunostaining for NeuN, CD34, MAP2, and IDH1. Each case was then independently classified by pathology or MRI as simple DNT, complex DNT, or dGNT. There was agreement in 23/27 (85%; Kappa score 0.62; p < 0.01). In 4 cases, there was discrepancy in the diagnosis of simple versus complex DNT but 100% agreement achieved for dGNT. DNT showed significantly more expansion of the cortex, cystic change and ventricle extension than dGNT. dGNT showed significantly more subcortical T2w hyperintensity and focal cortical atrophy which correlated on pathology with CD34 expression, cortical neuronal loss and white matter rarefaction. There was no distinct cortical dysplasia component identified by MRI or pathology in any case. This study highlights that dGNT can be reliably discriminated on MRI from DNT.
قاعدة البيانات:	Supplemental Index

الوصف
تدمد:	00223069 15546578
DOI:	10.1093/jnen/nlx090