دورية أكاديمية
Neurofilament light is a biomarker of brain involvement in lupus and primary Sjögren's syndrome
| العنوان: | Neurofilament light is a biomarker of brain involvement in lupus and primary Sjögren's syndrome |
|---|---|
| المؤلفون: | Tjensvoll, AB, Lauvsnes, MB, Zetterberg, H, Kvaløy, JT, Kvivik, I, Maroni, SS, Greve, OJ, Beyer, MK, Hirohata, S, Putterman, C, Alves, G, Harboe, E, Blennow, K, Gøransson, LG, Omdal, R |
| المصدر: | Journal of Neurology (2020) |
| سنة النشر: | 2020 |
| المجموعة: | University College London: UCL Discovery |
| مصطلحات موضوعية: | Neuroflament light chain · Anti-NR2 antibodies · Cognitive dysfunction · Systemic lupus erythematosus · Primary Sjögrens´s syndrome |
| الوصف: | Background: To test the hypothesis that neuroflament light (NfL) in CSF is a biomarker of CNS involvement in patients with systemic lupus erythematosus (SLE) and primary Sjögren’s syndrome (pSS), we measured NfL in CSF from 52 patients with lupus and 54 with pSS and explored associations with clinical, structural, immunological and biochemical abnormalities. Methods: In CSF, we measured NfL, anti-P antibodies, protein S100B and TWEAK by ELISA and anti-NR2 antibodies by electrochemiluminescence. Anti-phospholipid antibodies and routine immunological tests were performed in blood. IgG and albumin were measured in CSF and serum for assessment of the blood–brain barrier function (Q-albumin) and intrathecal IgG production (IgG index). Cerebral MRI and neuropsychological testing were performed. Results: A multivariable regression model showed that increasing CSF anti-NR2 antibody levels were associated with increasing NfL levels in patients with SLE (B 1.27, 95% CI 0.88–1.65, p<0.001). Age contributed signifcantly in the model (B 0.04, 95% CI 0.03–0.05, p<0.001). Similar fndings were observed in the pSS group. Adjusted for age and sex, no associations were found between NfL levels and any MRI data. In SLE patients, higher NfL concentrations were associated with impairments in psychomotor speed and motor function, and in pSS with motor dysfunction. These associations remained in multivariable regression models. Conclusions: Increased concentration of NfL in CSF is a marker of cerebral involvement in patients with SLE and pSS, is strongly associated with the presence of anti-NR2 antibodies, and correlates with cognitive impairment in several domains |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | text |
| اللغة: | English |
| العلاقة: | https://discovery.ucl.ac.uk/id/eprint/10114651/1/Tjensvoll2020_Article_NeurofilamentLightIsABiomarker.pdfTest; https://discovery.ucl.ac.uk/id/eprint/10114651Test/ |
| الإتاحة: | https://discovery.ucl.ac.uk/id/eprint/10114651/1/Tjensvoll2020_Article_NeurofilamentLightIsABiomarker.pdfTest https://discovery.ucl.ac.uk/id/eprint/10114651Test/ |
| حقوق: | open |
| رقم الانضمام: | edsbas.297E6288 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |