التفاصيل البيبلوغرافية
| العنوان: |
Light-emitting diode therapy protects against ventricular arrhythmias by neuro-immune modulation in myocardial ischemia and reperfusion rat model. |
| المؤلفون: |
Wang, Songyun, Wu, Lin, Li, Xuemeng, Li, Binxun, Zhai, Yi, Zhao, Dongdong, Jiang, Hong |
| المصدر: |
Journal of Neuroinflammation; 7/8/2019, Vol. 16 Issue 1, pN.PAG-N.PAG, 1p |
| مصطلحات موضوعية: |
VENTRICULAR arrhythmia, MYOCARDIAL reperfusion, CORONARY disease, DIODES, CARDIOVASCULAR diseases, VENTRICULAR fibrillation treatment, ANIMALS, IMMUNITY, MYOCARDIAL reperfusion complications, PHOTOTHERAPY, RATS, STATISTICAL sampling, VENTRICULAR fibrillation, PHYSIOLOGICAL effects of radiation |
| مستخلص: |
Background: Sympathetic overactivation and inflammation are two major mediators to post-myocardial ischemia-reperfusion (I/R)-induced ventricular arrhythmia (VA). The vicious cycle between microglia and sympathetic activation plays an important role in sympathetic hyperactivity related to cardiovascular diseases. Recently, studies have shown that microglial activation might be attenuated by light-emitting diode (LED) therapy. Therefore, we hypothesized that LED therapy might protect against myocardial I/R-induced VAs by attenuating microglial and sympathetic activation.Methods: Thirty-six male anesthetized rats were randomized into four groups: control group (n = 6), LED group (n = 6), I/R group (n = 12), and LED+I/R group (n = 12). I/R was generated by left anterior descending artery occlusion for 30 min followed by 3 h reperfusion. ECG and left stellate ganglion (LSG) neural activity were recorded continuously. After 3 h reperfusion, a programmed stimulation protocol was conducted to test the inducibility of VA. Furthermore, we extracted the brain tissue to examine the microglial activation, and the peri-ischemic myocardium to examine the expression of NGF and inflammatory cytokines (IL-1β, IL-18, IL-6, and TNF-α).Results: As compared to the I/R group, LED illumination significantly inhibited the LSG neural activity (P < 0.01) and reduced the inducibility of VAs (arrhythmia score 4.417 ± 0.358 vs. 3 ± 0.3257, P < 0.01) in the LED+I/R group. Furthermore, LED significantly attenuated microglial activation and downregulated the expression of inflammatory cytokines and NGF in the peri-infarct myocardium.Conclusions: LED therapy may protect against myocardial I/R-induced VAs by central and peripheral neuro-immune regulation. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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