التفاصيل البيبلوغرافية
| العنوان: |
The selective Rho-kinase inhibitor Fasudil is protective and therapeutic in experimental autoimmune encephalomyelitis |
| المؤلفون: |
Sun, Xiaojia1, Minohara, Motozumi1, Kikuchi, Hitoshi1, Ishizu, Takaaki1, Tanaka, Masahito1, Piao, Hua1, Osoegawa, Manabu1, Ohyagi, Yasumasa1, Shimokawa, Hiroaki2, Kira, Jun-ichi1 kira@neuro.med.kyushu-u.ac.jp |
| المصدر: |
Journal of Neuroimmunology. Nov2006, Vol. 180 Issue 1/2, p126-134. 9p. |
| مصطلحات موضوعية: |
*BASIC proteins, *CENTRAL nervous system diseases, *MULTIPLE sclerosis, *LEUCOCYTES |
| مستخلص: |
Abstract: We studied the role of fasudil, a selective Rho-kinase inhibitor, in experimental autoimmune encephalomyelitis (EAE). Both parenteral and oral administration of fasudil prevented the development of EAE induced by proteolipid protein (PLP) p139-151 in SJL/J mice. Specific proliferation of lymphocytes to PLP was significantly reduced, together with a downregulation of interleukin (IL)-17 and a marked decrease of the IFN-γ/IL-4 ratio. Immunohistochemical examination also disclosed a marked decrease of inflammatory cell infiltration, and attenuated demyelination and acute axonal transaction. These results may provide a rationale of selective blockade of Rho-kinase by oral use of fasudil as a new therapy for multiple sclerosis. [Copyright &y& Elsevier] |
| قاعدة البيانات: |
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