التفاصيل البيبلوغرافية
| العنوان: |
Prostaglandin H[sub 2] (PGH[sub 2] ) accelerates formation of amyloid β[sub 1-42] oligomers. |
| المؤلفون: |
Boutaud, Olivier, Ou, Joyce J., Chaurand, Pierre, Caprioli, Richard M., Montine, Thomas J., Oates, John A. |
| المصدر: |
Journal of Neurochemistry; 8/15/2002, Vol. 82 Issue 4, p1003, 4p |
| مصطلحات موضوعية: |
AMYLOID, OLIGOMERS, PROSTAGLANDINS, CYCLOOXYGENASES |
| مستخلص: |
Epidemiologic evidence implicates cyclooxygenase activity in the pathogenesis of Alzheimer's disease, in which amyloid plaques have been found to contain increased levels of dimers and higher multimers of the amyloid β peptide. The product of the oxygenation of arachidonic acid by the cyclooxygenases, prostaglandin H[sub 2] (PGH[sub 2]), rearranges non-enzymatically to several prostaglandins, including the highly reactive γ-keto aldehydes, levuglandins E[sub 2] and D[sub 2]. We demonstrate that PGH[sub 2] markedly accelerates the formation of dimers and higher oligomers of amyloid β[sub 1]-42- This is associated with the formation of levuglandin adducts of the peptide. These findings provide the molecular basis for a hypothesis linking cyclooxygenase activity to the formation of oligomers of amyloid β. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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