التفاصيل البيبلوغرافية
| العنوان: |
Direct influence of antidepressants on GTP binding protein of adenylate cyclase in cell membranes of the cerebral cortex of rats. |
| المؤلفون: |
Yamaoka, K., Nanba, T., Nomura, S. |
| المصدر: |
Journal of Neural Transmission; 1988, Vol. 71 Issue 3, p165-175, 11p |
| مستخلص: |
Recently, it has been suggested that antidepressant drugs exert their pharmacological action through functional changes in the adrenergic-receptor coupled adenylate cyclase system. In the present research, we examined the direct effects of antidepressants on adenylate cyclase (A-cyclase) activity by in vitro incubation of cell membranes from the cerebral cortex of rats with these drugs. All antidepressants examined, such as imipramine, clomipramine, amitriptyline, desipramine, mianserin and zimelidine inhibited A-cyclase in a dose dependent manner. Antidepressants did not exert any influence on Mn-induced elevation of A-cyclase, but significantly suppressed F-stimulated A-cyclase activity. GTP-induced elevation of A-cyclase was completely inhibited by prior incubation with antidepressants. Our conclusion, therefore, is that antidepressants may reduce A-cyclase activity not by inhibiting the function of the catalytic unit of A-cyclase, but by supressing the N-protein function. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
