التفاصيل البيبلوغرافية
العنوان:
Parkinson’s disease-associated DJ-1 modulates innate immunity signaling in Caenorhabditis elegans
المؤلفون:
Jens Waak , Stephanie Weber , Philipp Oberhettinger , Monika Schütz , Wolfdieter Springer , Ingo B. Autenrieth , Fabienne C. Fiesel , Philipp J. Kahle , Elena M. Cornejo Castro
المصدر:
Journal of neural transmission 117(5), 599-604 (2010). doi:10.1007/s00702-010-0397-4
بيانات النشر:
Springer Science and Business Media LLC, 2010.
سنة النشر:
2010
مصطلحات موضوعية:
metabolism [Caenorhabditis elegans Proteins] , metabolism [Zebrafish Proteins] , metabolism [Mitogen-Activated Protein Kinases] , physiology [Gene Expression Regulation] , metabolism [Parkinson Disease] , immunology [Signal Transduction] , genetics [Zebrafish Proteins] , Nerve Tissue Proteins , Biology , Neuroprotection , Gene Knockout Techniques , immunology [Parkinson Disease] , genetics [Parkinson Disease] , Immunity , Animals , ddc:610 , Phosphorylation , Caenorhabditis elegans , Caenorhabditis elegans Proteins , Protein kinase A , genetics [Nerve Tissue Proteins] , Biological Psychiatry , physiology [Phosphorylation] , park7 protein, zebrafish , Regulation of gene expression , metabolism [Nerve Tissue Proteins] , Innate immune system , genetics [Caenorhabditis elegans Proteins] , Parkinson Disease , metabolism [Caenorhabditis elegans] , Zebrafish Proteins , biology.organism_classification , Immunity, Innate , Pmk-1 protein, C elegans , Cell biology , genetics [Immunity, Innate] , Psychiatry and Mental health , Gene Expression Regulation , Neurology , genetics [Caenorhabditis elegans] , Neurology (clinical) , Mitogen-Activated Protein Kinases , Signal transduction , Signal Transduction , immunology [Caenorhabditis elegans]
الوصف:
DJ-1 is a neuroprotective gene mutated in recessive Parkinson's disease (PD). In addition to direct protective functions in neurons, DJ-1 regulates neuroinflammatory signaling in primary mouse brain astrocytes. To assess the influence of DJ-1 on innate immunity signaling in vivo, we have generated djr-1 knockout Caenorhabditis elegans. When grown on pathogenic gram-negative bacteria, djr-1 (-/-) worms showed stronger phosphorylation of p38 mitogen-activated protein kinase (PMK-1) and hyper-induction of PMK-1 target genes. Thus, PD-associated DJ-1 contributes to regulation of innate immunity.
تدمد:
1435-1463
الوصول الحر:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90dfdfb0238e8b96e5f5db3e1f55f482Test https://doi.org/10.1007/s00702-010-0397-4Test
حقوق:
CLOSED
رقم الانضمام:
edsair.doi.dedup.....90dfdfb0238e8b96e5f5db3e1f55f482
قاعدة البيانات:
OpenAIRE
