دورية
Growth in children with chronic kidney disease: 13 years follow up study
| العنوان: | Growth in children with chronic kidney disease: 13 years follow up study |
|---|---|
| المؤلفون: | Salević, Petar, Radović, Pavle, Milić, Nataša, Bogdanović, Radovan, Paripović, Dušan, Paripović, Aleksandra, Golubović, Emilija, Milosević, Biljana, Mulić, Bilsana, Peco-Antić, Amira |
| المصدر: | Journal of Nephrology; October 2014, Vol. 27 Issue: 5 p537-544, 8p |
| مستخلص: | Growth retardation is one of the most visible comorbid conditions of chronic kidney disease (CKD) in children. To our knowledge, published data on longitudinal follow-up of growth in pediatric patients with CKD is lacking from the region of South-East Europe. Herein we report the results from the Serbian Pediatric Registry of Chronic Kidney Disease. The data reported in the present prospective analysis were collected between 2000 and 2012. A total of 324 children with CKD were enrolled in the registry. Prevalence of growth failure at registry entry was 29.3 %. Mean height standard deviation scores (HtSDS) in children with stunting and those with normal stature were −3.00 [95 % confidence interval (CI) −3.21 to −2.79] and −0.08 (95 % CI −0.22 to 0.05) (p < 0.001), respectively. Children with hereditary nephropathy had worse growth at registration (−1.51; 95 % CI −1.97 to −1.04, p = 0.008). Those with CKD stages 4 and 5 before registration had more chance to have short stature at registration than those with CKD stages 2 and 3 [odds ratio (OR) = 0.458, CI 0.268–0.782, p = 0.004]. Dialysis was an independent negative predictor for maintaining optimal stature during the follow-up period (OR = 0.324, CI = 0.199–0.529, p < 0.001), while transplantation was an independent positive predictor for improvement of small stature during follow-up (OR = 3.706, CI = 1.785–7.696, p < 0.001). Growth failure remains a significant problem in children with CKD, being worst in patients with hereditary renal disease. Growth is not improved by standard dialysis, but transplantation has a positive impact on growth in children. |
| قاعدة البيانات: | Supplemental Index |
| تدمد: | 11218428 17246059 |
|---|---|
| DOI: | 10.1007/s40620-014-0094-8 |