التفاصيل البيبلوغرافية
العنوان:
Xenortide Biosynthesis by Entomopathogenic Xenorhabdus nematophila
المؤلفون:
Daniela Reimer , Katharina Schultz , Friederike I. Nollmann , Helge B. Bode , Marcel Kaiser
المصدر:
Journal of Natural Products . 77:1976-1980
بيانات النشر:
American Chemical Society (ACS), 2014.
سنة النشر:
2014
مصطلحات موضوعية:
Plasmodium falciparum , Trypanosoma brucei brucei , Pharmaceutical Science , Trypanosoma brucei , 01 natural sciences , Xenorhabdus , Analytical Chemistry , Microbiology , 03 medical and health sciences , chemistry.chemical_compound , Parasitic Sensitivity Tests , Biosynthesis , parasitic diseases , Drug Discovery , Gene cluster , Nuclear Magnetic Resonance, Biomolecular , Chromatography, High Pressure Liquid , 030304 developmental biology , Leishmania , Pharmacology , 0303 health sciences , Xenorhabdus nematophila , Molecular Structure , biology , 010405 organic chemistry , Xenortide D , Organic Chemistry , Ms analysis , Dipeptides , biology.organism_classification , Tryptamines , 0104 chemical sciences , 3. Good health , Complementary and alternative medicine , chemistry , Biochemistry , Multigene Family , Molecular Medicine
الوصف:
The biosynthesis gene cluster of the xenortides and a new derivative, xenortide D, which is produced in only trace amounts, was identified in Xenorhabdus nematophila. The structure of xenortide D was elucidated using a combination of labeling experiments followed by MS analysis and was confirmed by synthesis. Bioactivity tests revealed a weak activity of tryptamine-carrying xenortides against Plasmodium falciparum and Trypanosoma brucei.
تدمد:
1520-6025
الوصول الحر:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f243d15689ac6b92db6820ae8ef2913dTest https://doi.org/10.1021/np500390bTest
رقم الانضمام:
edsair.doi.dedup.....f243d15689ac6b92db6820ae8ef2913d
قاعدة البيانات:
OpenAIRE
