Irpeksins A–E, 1,10-seco-Eburicane-Type Triterpenoids from the Medicinal Fungus Irpex lacteus and Their Anti-NO Activity
| العنوان: | Irpeksins A–E, 1,10-seco-Eburicane-Type Triterpenoids from the Medicinal Fungus Irpex lacteus and Their Anti-NO Activity |
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| المؤلفون: | Yang Tang, Jian-Neng Yao, Zheng-Hui Li, Ji-Kai Liu, He-Ping Chen, Tao Feng, Zhen-Zhu Zhao |
| المصدر: | Journal of Natural Products. 81:2163-2168 |
| بيانات النشر: | American Chemical Society (ACS), 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Magnetic Resonance Spectroscopy, Stereochemistry, Irpex lacteus, Pharmaceutical Science, Fungus, Nitric Oxide, 010402 general chemistry, Cleavage (embryo), Ring (chemistry), 01 natural sciences, Lanostane, Analytical Chemistry, Mice, chemistry.chemical_compound, Ascomycota, Drug Discovery, Animals, RAW 264.7 Cells, Pharmacology, Molecular Structure, biology, 010405 organic chemistry, Organic Chemistry, Nuclear magnetic resonance spectroscopy, biology.organism_classification, Triterpenes, 0104 chemical sciences, Complementary and alternative medicine, chemistry, Molecular Medicine, Polyporales |
| الوصف: | Five new triterpenoids, irpeksins A-E (1-5), were isolated from fruiting bodies of the medicinal fungus Irpex lacteus. The structures as well as absolute configurations of the new compounds were established via extensive spectroscopic analysis, computational methods, and Cotton effects. Compounds 1-4 are featured by a scaffold of 1,10- seco- and ring B aromatic eburicane (24-methyllanostane), and compound 5 is characterized by a scaffold of 1,10-9,11- diseco- and ring B aromatic eburicane, which represents unprecedented cleavage patterns in the lanostane family. Compounds 1-5 showed significant inhibitory activity against NO production in LPS-activated RAW 264.7 macrophage cells with IC50 values varying from 2.2 to 19.6 μM. |
| تدمد: | 1520-6025 0163-3864 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32031a6ca6e9f480eb5b01ac69da5b5eTest https://doi.org/10.1021/acs.jnatprod.7b00845Test |
| رقم الانضمام: | edsair.doi.dedup.....32031a6ca6e9f480eb5b01ac69da5b5e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15206025 01633864 |
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