Neolignans from Aristolochia fordiana Prevent Oxidative Stress-Induced Neuronal Death through Maintaining the Nrf2/HO-1 Pathway in HT22 Cells
| العنوان: | Neolignans from Aristolochia fordiana Prevent Oxidative Stress-Induced Neuronal Death through Maintaining the Nrf2/HO-1 Pathway in HT22 Cells |
|---|---|
| المؤلفون: | Min Tan, Zhongbin Cheng, Ting-Ting Lin, Jing-Mei Bao, Ziwei Chen, Zhang-Hua Sun, Sheng Yin, Xiao-Yun Gao, Gui-Hua Tang, Gang Huang |
| المصدر: | Journal of Natural Products. 78:1894-1903 |
| بيانات النشر: | American Chemical Society (ACS), 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Programmed cell death, Circular dichroism, Antioxidant, Cell Survival, NF-E2-Related Factor 2, medicine.medical_treatment, Blotting, Western, Glutamic Acid, Pharmaceutical Science, Apoptosis, Endogeny, Biology, medicine.disease_cause, Hippocampus, Neuroprotection, Antioxidants, Lignans, Analytical Chemistry, chemistry.chemical_compound, Drug Discovery, medicine, Nuclear Magnetic Resonance, Biomolecular, Heme, Benzofurans, Neurons, Pharmacology, Cell Death, L-Lactate Dehydrogenase, Molecular Structure, Plant Stems, Organic Chemistry, Aristolochia, Oxidative Stress, Neuroprotective Agents, Proto-Oncogene Proteins c-bcl-2, Complementary and alternative medicine, chemistry, Biochemistry, Cell culture, Molecular Medicine, Reactive Oxygen Species, Heme Oxygenase-1, Oxidative stress, Drugs, Chinese Herbal, Signal Transduction |
| الوصف: | Bioassay-guided fractionation of the ethanolic extract of the stems of Aristolochia fordiana led to the isolation of six new dihydrobenzofuran neolignans (1-3 and 7-9), three new 2-aryldihydrobenzofurans (4-6), a new 8-O-4' neolignan (10), and 14 known analogues (11-24). The structures of compounds 1-10 were established by spectroscopic methods, and their absolute configurations were determined by analyses of the specific rotation and electronic circular dichroism data. The neuroprotective effects of compounds 1-24 against glutamate-induced cell death were tested in hippocampal neuronal cell line HT22. Compounds 17 and 20-24 exhibited moderate neuroprotective activity by increasing the endogenous antioxidant defense system. In addition, the neolignans activated the Nrf2 (nuclear factor E2-related factor 2) pathway, resulting in the increase of the expression of endogenous antioxidant protein HO-1 (heme oxygenase-1). The active compounds also preserved the levels of antiapoptotic protein Bcl-2 (B cell lymphoma/leukemia-2), which was decreased by glutamate. Collectively, these results suggested that the active neolignans protect neurons against glutamate-induced cell death through maintaining the Nrf2/HO-1 signaling pathway as well as preserving the Bcl-2 protein and might be promising novel beneficial agents for oxidative stress-associated diseases. |
| تدمد: | 1520-6025 0163-3864 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ede2ab154dfa77ccde43873312e1e41bTest https://doi.org/10.1021/acs.jnatprod.5b00220Test |
| رقم الانضمام: | edsair.doi.dedup.....ede2ab154dfa77ccde43873312e1e41b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15206025 01633864 |
|---|