Effect of heat processing on the chemical constituents and NO-suppressing activity of Bletilla Tuber
| العنوان: | Effect of heat processing on the chemical constituents and NO-suppressing activity of Bletilla Tuber |
|---|---|
| المؤلفون: | Chiaki Murayama, Ken Tanaka, Tetsuya Okuyama, Mikio Nishizawa, Ryo Okada, Hisayoshi Norimoto, Yuto Nishidono, Toshinari Ishii, Dingxiang He |
| المصدر: | Journal of Natural Medicines. 74:219-228 |
| بيانات النشر: | Springer Science and Business Media LLC, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Hot Temperature, Heat processing, Astringent, Anti-Inflammatory Agents, 01 natural sciences, chemistry.chemical_compound, Bletilla striata, Bibenzyls, Ic50 values, Bibenzyl, Chinese pharmacopoeia, Orchidaceae, Plants, Medicinal, Bletilla, Traditional medicine, biology, 010405 organic chemistry, fungi, food and beverages, Phenanthrenes, biology.organism_classification, 0104 chemical sciences, Plant Tubers, 010404 medicinal & biomolecular chemistry, chemistry, Chemical constituents, Molecular Medicine, Drugs, Chinese Herbal, Phytotherapy |
| الوصف: | Bletilla Tuber (dried tuber of Bletilla striata) is used as an astringent hemostatic medicine for the treatment of ulcers, bleeding, and burns in traditional Chinese medicine (TCM). The Chinese Pharmacopoeia describes the heat processing methods used on raw tubers of Bletilla striata to produce the herbal medicine "Bletilla Tuber". In this study, we compared the chemical constituents of well-processed Bletilla Tuber (BT1) and normally processed Bletilla Tuber (BT2) derived from the same origin. In addition, as an indicator of the hemostatic activity of Bletilla Tuber, the NO inhibitory activities of extracts obtained from BT1 and BT2 and the isolated compounds were examined. As a result of LC–MS analysis, three types of compounds, glucosyloxybenzyl 2-isobutylmalates, bibenzyl derivatives and phenanthrene derivatives, were detected. Comparison of the chemical profiles of the extracts indicated that the relative contents of glucosyloxybenzyl 2-isobutylmalates had changed by heat processing, whereas the relative contents of bibenzyls and phenanthrenes had not changed. The extracts of BT1 and BT2 showed similar IC50 values on NO production suppressing activity. Furthermore, phenanthrenes and bibenzyls were identified as the compounds responsible for suppressing the NO activity. These results suggest that the biological activities, such as the anti-inflammatory and hemostatic activities, of Bletilla Tuber are not affected by heat processing. |
| تدمد: | 1861-0293 1340-3443 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04e888336ef2429624e3f1e2f9046e25Test https://doi.org/10.1007/s11418-019-01371-yTest |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....04e888336ef2429624e3f1e2f9046e25 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 18610293 13403443 |
|---|