Enhanced anti-immobility effects of Sanggenon G isolated from the root bark of Morus alba combined with the α2-antagonist yohimbine in the rat forced swim test
| العنوان: | Enhanced anti-immobility effects of Sanggenon G isolated from the root bark of Morus alba combined with the α2-antagonist yohimbine in the rat forced swim test |
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| المؤلفون: | Chang-Ho Lee, Nam-In Baek, Inho Kim, Yun Tai Kim, Dong Wook Lim, Daeseok Han |
| المصدر: | Journal of Natural Medicines. 70:679-682 |
| بيانات النشر: | Springer Science and Business Media LLC, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, medicine.medical_specialty, Serotonin reuptake inhibitor, Sanggenon G, Pharmacology, Rats, Sprague-Dawley, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, Animals, Swimming, Benzofurans, Fluoxetine, Depression, Chemistry, Antagonist, Yohimbine, Rats, 030104 developmental biology, Endocrinology, Chromones, Active compound, visual_art, visual_art.visual_art_medium, Molecular Medicine, Bark, Morus, 030217 neurology & neurosurgery, Behavioural despair test, medicine.drug |
| الوصف: | In this study, we aimed to determine whether Sanggenon G, an active compound isolated from the root bark of Morus alba, exhibited enhanced anti-immobility activity with the addition of the α2-antagonist yohimbine in rats subjected to forced swim test (FST)-induced depression. Fluoxetine (a selective serotonin reuptake inhibitor) treatment in rats reduced the immobility time, and pretreatment with yohimbine significantly enhanced the antidepressant-like behavior of fluoxetine at 5, 10 and 20 mg/kg. Similarly, Sanggenon G significantly decreased the immobility time, reducing immobility by a maximum of 43.9 % when treated at a dose of 20 mg/kg. Furthermore, pretreatment with yohimbine significantly enhanced the antidepressant-like behavior of Sanggenon G at 5 and 10 mg/kg. Our findings suggest that the antidepressant-like effect of Sanggenon G could be facilitated by concomitant use of the α2-antagonist. Further studies are needed to evaluate the potential of Sanggenon G as an alternative therapeutic approach for the treatment of depression. |
| تدمد: | 1861-0293 1340-3443 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7c9d73e0d321283574207b9562cf6e2Test https://doi.org/10.1007/s11418-016-0975-3Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....f7c9d73e0d321283574207b9562cf6e2 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 18610293 13403443 |
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