التفاصيل البيبلوغرافية
| العنوان: |
Facile synthesis and nanoscale features of a nanostructured nordihydroguaiaretic acid analog for therapeutic applications. |
| المؤلفون: |
John, Geraldine Sandana Mala, Vuttaradhi, Veena Kumari, Takeuchi, Satoru, Pitani, Ravi Shankar, Venkatraman, Ganesh, Rayala, Suresh Kumar |
| المصدر: |
Journal of Nanobiotechnology; 5/14/2020, Vol. 18 Issue 1, p1-16, 16p |
| مصطلحات موضوعية: |
CHEMICAL derivatives, POLYCAPROLACTONE, POLYETHYLENE glycol, CHEMICAL synthesis |
| مستخلص: |
Background: Nordihydroguaiaretic acid (NDGA) is a plant lignan obtained from creosote bush, known to possess anti-oxidant, anti-cancer and anti-viral activities and is being used in traditional medicine. However, toxicity studies indicated liver and kidney damage despite its immense medicinal properties. There has been a recent increase of curiosity in the chemical synthesis of NDGA derivatives for therapeutic applications. NDGA derivatives have been developed as better alternatives to NDGA and for targeted delivery to the site of tissue by chemical derivatives. In this regard, an analog of NDGA, Acetyl NDGA (Ac-NDGA), has been synthesized based on a previous procedure and formulated as a nanostructured complex with Polycaprolactone/Polyethylene glycol polymer matrices, by o/w solvent evaporation method. Results: The drug-incorporated polymeric nanospheres exhibited a drug load of 10.0 ± 0.5 µg drug per mg of nanospheres in acetonitrile solvent with 49.95 ± 10% encapsulation efficiency and 33–41% drug loading capacity with different batches of nanospheres preparation. The in vitro drug release characteristics indicated 82 ± 0.25% drug release at 6 h in methanol. Further, the nanospheres have been characterized extensively to evaluate their suitability for therapeutic delivery. Conclusions: The present studies indicate a new and efficient formulation of the nanostructured AcNDGA with good therapeutic potential. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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