دورية
Relationships Between Knee Pain and Osteoarthritis Biomarkers Based on Systemic Fluids and Magnetic Resonance Imaging
| العنوان: | Relationships Between Knee Pain and Osteoarthritis Biomarkers Based on Systemic Fluids and Magnetic Resonance Imaging |
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| المؤلفون: | Dam, Erik B, Byrjalsen, Inger, Arendt-Nielsen, Lars, Christiansen, Claus, Karsdal, Morten A |
| المصدر: | Journal of Musculoskeletal Pain; July 2011, Vol. 19 Issue: 3 p144-153, 10p |
| مستخلص: | ObjectivesPain relief and joint space narrowing prevention are the clinically accepted evidence of effective osteoarthritis [OA] treatment. However, previous studies show no clear correlation between them. In this 21-month non-treatment study, we investigated relationships between alternative OA biomarkers and knee pain.MethodsOne hundred fifty-nine subjects were recruited, including healthy volunteers with known knee problems. Two biochemical degradation markers were measured; a serum bone marker [sCTX-I] and a urinary cartilage marker [uCTX-II]. Seven magnetic resonance imaging biomarkers were measured, assessing cartilage volume, thickness, curvature, smoothness, and homogeneity. Joint space width was measured from radiographs. All imaging markers were measured in the medial tibio-femoral compartments.The knee pain during the previous 24 hours was scored by a visual analog scale. Biomarkers were measured at baseline and follow-up, except for pain that was only scored at follow-up. The relationships to pain presence and severity were evaluated cross-sectionally at follow-up and longitudinally to biomarker changes from baseline to follow-up.ResultsThe analysis included 134 subjects with baseline age 56 ??±±?? 16, body mass index [BMI] 26 ??±±?? 4, and 53 percent without radiographic OA. After normalization for gender, age, and BMI, the strongest cross-sectional relationship to pain presence was uCTX-II [receiver-operators characteristics area], area under the curve [AUC] 0.65, P?? |
| قاعدة البيانات: | Supplemental Index |
| تدمد: | 10582452 15407012 |
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| DOI: | 10.3109/10582452.2011.582988 |