Parkinson’s Disease Genetic Loci in Rapid Eye Movement Sleep Behavior Disorder
| العنوان: | Parkinson’s Disease Genetic Loci in Rapid Eye Movement Sleep Behavior Disorder |
|---|---|
| المؤلفون: | Simon Girard, Christelle Charley Monaca, Jean-François Gagnon, Guy A. Rouleau, Thomas Mitterling, Alex Desautels, V. Cochen De Cock, C. Mirarchi, Patrick A. Dion, Anne Noreau, Isabelle Arnulf, Birgit Högl, Claire S. Leblond, Ziv Gan-Or, Birgit Frauscher, Jacques Montplaisir, Yves Dauvilliers, Ronald B. Postuma |
| المساهمون: | Fédération des Pathologies du Sommeil, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Hôpital Gui de Chauliac, Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Neuropsychiatrie : recherche épidémiologique et clinique (PSNREC), Université Montpellier 1 (UM1)-Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Euromov (EuroMov), Université de Montpellier (UM), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier) |
| المصدر: | Journal of Molecular Neuroscience Journal of Molecular Neuroscience, Humana Press, 2015, 56 (3), pp.617-622. ⟨10.1007/s12031-015-0569-7⟩ |
| بيانات النشر: | Springer Science and Business Media LLC, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Male, Oncology, medicine.medical_specialty, Neurology, Parkinson's disease, Rapid eye movement sleep, tau Proteins, REM Sleep Behavior Disorder, Disease, Polymorphism, Single Nucleotide, REM sleep behavior disorder, 03 medical and health sciences, Cellular and Molecular Neuroscience, 0302 clinical medicine, Internal medicine, medicine, Humans, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, Neurochemistry, Survival analysis, Aged, 030304 developmental biology, Receptors, Scavenger, Synucleinopathies, 0303 health sciences, Lysosome-Associated Membrane Glycoproteins, Parkinson Disease, General Medicine, Middle Aged, medicine.disease, 3. Good health, Genetic Loci, Case-Control Studies, Female, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Psychology, Ubiquitin Thiolesterase, Neuroscience, 030217 neurology & neurosurgery |
| الوصف: | International audience; Rapid eye movement (REM) sleep behavior disorder (RBD) is a prodromal condition for Parkinson's disease (PD) and other synucleinopathies, which often occurs many years before the onset of PD. We analyzed 261 RBD patients and 379 controls for nine PD-associated SNPs and examined their effects, first upon on RBD risk and second, on eventual progression to synucleinopathies in a prospective follow-up in a subset of patients. The SCARB2 rs6812193 (OR = 0.67, 95 % CI = 0.51-0.88, p = 0.004) and the MAPT rs12185268 (OR-0.43, 95 % CI-0.26-0.72, p = 0.001) were associated with RBD in different models. Kaplan-Meier survival analysis in a subset of RBD patients (n = 56), demonstrated that homozygous carriers of the USP25 rs2823357 SNP had progressed to synucleinopathies faster than others (log-rank p = 0.003, Breslow p = 0.005, Tarone-Ware p = 0.004). As a proof-of-concept study, these results suggest that RBD may be associated with at least a subset of PD-associated genes, and demonstrate that combining genetic and prodromal clinical data may help identifying individuals that are either more or less susceptible to develop synucleinopathies. More studies are necessary to replicate these results, and identify more genetic factors affecting progression from RBD to synucleinopathies. |
| تدمد: | 1559-1166 0895-8696 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7e33391700756f0ad67b6566423fe0aTest https://doi.org/10.1007/s12031-015-0569-7Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....e7e33391700756f0ad67b6566423fe0a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15591166 08958696 |
|---|