التفاصيل البيبلوغرافية
| العنوان: |
Sub-nanoliter nuclear magnetic resonance coils fabricated with multilayer soft lithography. |
| المؤلفون: |
Matthew H C, Mark A Homenuke, Carl A Michal, Carl L Hansen |
| المصدر: |
Journal of Micromechanics & Microengineering; Sep2009, Vol. 19 Issue 9, p095001-095001, 1p |
| مصطلحات موضوعية: |
MICROFABRICATION, NANOWIRES, NUCLEAR magnetic resonance, LITHOGRAPHY, RADIO transmitter-receivers, PLASMA desorption mass spectrometry, MICROFLUIDICS, FINITE element method, SIMULATION methods & models |
| مستخلص: |
We describe the fabrication and characterization of sub-nanoliter volume nuclear magnetic resonance (NMR) transceiver coils that are easily amenable to integration within PDMS-based microfluidics. NMR coils were constructed by the injection of liquid metal into solenoidal cavities created around a microchannel using consecutive replica molding and bonding of PDMS layers. This construction technique permits the integration of NMR coils with solenoidal, toroidal or other three-dimensional geometries within highly integrated microfluidic systems and are one step toward NMR-based chemical screening and analysis on chip. The current proof-of-principle implementation displays limited sensitivity and resolution due to the conductivity and magnetic susceptibilities of the construction materials. However, NMR measurements and finite-element simulations made with the current device geometry indicate that optimization of these materials will allow for the collection of spectra from sub-millimolar concentration samples in less than 1 nL of solution. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
