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1
المؤلفون: Dillon H. Miles, Ada Chen, Manmohan Reddy Leleti, Divyank Soni, Stephen W Young, Artur K. Mailyan, Kenneth V. Lawson, Stefan G Shaqfeh, Ehesan U. Sharif, Jenna L. Jeffrey, Jesus Banuelos, Xuelei Yan, Samuel L Drew, Kimberline Gerrick, Nigel Walker, Puja Dhanota, Lixia Jin, Jay P. Powers, Elaine Ginn, Guillaume Mata, Kent Wong, Hema Singh, Jeremy Fournier, Joel W. Beatty, Ulrike Schindler, Amber Pham, Matthew J. Walters, Jie Chen, Cesar Meleza, Xiaoning Zhao, Nell Narasappa
المصدر: Journal of Medicinal Chemistry. 65:1418-1444
مصطلحات موضوعية: Male, Pyrazolopyrimidine, Rats, Sprague-Dawley, Structure-Activity Relationship, chemistry.chemical_compound, Immune system, Amide, Drug Discovery, Animals, Class Ib Phosphatidylinositol 3-Kinase, Humans, Structure–activity relationship, Potency, Phosphoinositide-3 Kinase Inhibitors, Phosphoinositide 3-kinase, biology, Amides, Phenotype, In vitro, Rats, Molecular Docking Simulation, Pyrimidines, chemistry, Biochemistry, Drug Design, biology.protein, Molecular Medicine
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b37aec4464f4375ff8b99d31a40b9e89Test
https://doi.org/10.1021/acs.jmedchem.1c01153Test -
2
المؤلفون: Dillon H. Miles, Nigel Walker, Manmohan Reddy Leleti, Xiaoning Zhao, Eric T. Newcomb, Kenneth V. Lawson, Jaroslaw Kalisiak, Erick Allen Lindsey, Lixia Jin, Ada Chen, Laurent Debien, Guifen Xu, Ehesan U. Sharif, Norbert Sträter, Brandon Reid Rosen, Stephen W Young, Emma Scaletti, Jay P. Powers
المصدر: Journal of Medicinal Chemistry. 64:845-860
مصطلحات موضوعية: Adenosine, Phosphorous Acids, Drug Evaluation, Preclinical, Molecular Dynamics Simulation, Crystallography, X-Ray, GPI-Linked Proteins, 01 natural sciences, Structure-Activity Relationship, 03 medical and health sciences, Immune system, ATP hydrolysis, Drug Discovery, medicine, Extracellular, Humans, Ectonucleotidase, 5'-Nucleotidase, 030304 developmental biology, chemistry.chemical_classification, 0303 health sciences, Tumor microenvironment, Binding Sites, Adenosine receptor, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Enzyme, chemistry, Biochemistry, Drug Design, Molecular Medicine, medicine.drug
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d84eb5999417f66c4c65efddd2d03a7Test
https://doi.org/10.1021/acs.jmedchem.0c01835Test -
3
المؤلفون: Dillon H. Miles, Ada Chen, Manmohan Reddy Leleti, Divyank Soni, Stephen W Young, Artur K. Mailyan, Kenneth V. Lawson, Stefan G Shaqfeh, Ehesan U. Sharif, Pei-Yu Chen, Jenna L. Jeffrey, Jesus Banuelos, Xuelei Yan, Samuel L Drew, Nigel Walker, Puja Dhanota, Lixia Jin, Jay P. Powers, Elaine Ginn, Guillaume Mata, Kent Wong, Jeremy Fournier, Joel W. Beatty, Rhiannon Thomas-Tran, Ulrike Schindler, Amber Pham, Matthew J. Walters, Jie Chen, Cesar Meleza, Xiaoning Zhao
المصدر: Journal of Medicinal Chemistry. 63:11235-11257
مصطلحات موضوعية: Gene isoform, Stereochemistry, Crystallography, X-Ray, 01 natural sciences, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, Drug Discovery, Animals, Class Ib Phosphatidylinositol 3-Kinase, Humans, Binding site, Phosphoinositide-3 Kinase Inhibitors, 030304 developmental biology, chemistry.chemical_classification, 0303 health sciences, Trifluoromethyl, Bicyclic molecule, Lipid signaling, Rats, 0104 chemical sciences, Molecular Docking Simulation, 010404 medicinal & biomolecular chemistry, Enzyme, chemistry, Drug Design, Molecular Medicine, Selectivity, Adenosine triphosphate
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::237c477c3969b94ce636dfc76aca3e4fTest
https://doi.org/10.1021/acs.jmedchem.0c01203Test -
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المؤلفون: Brandon Reid Rosen, Manmohan Reddy Leleti, Ada Chen, Sharon Zhao, Jenna L. Jeffrey, Norbert Sträter, Eric T. Newcomb, Jay P. Powers, Kenneth V. Lawson, Lijuan Fu, Dillon H. Miles, Uli Schindler, Wade Berry, Stephen W Young, Tim Park, Emma Scaletti, Lixia Jin, Joanne B.L. Tan, Ehesan U. Sharif, Laurent Debien, Erick Allen Lindsey, Jaroslaw Kalisiak, Susanne Moschütz, Matthew J. Walters, Guifen Xu, Nigel Walker
المصدر: Journal of Medicinal Chemistry. 63:11448-11468
مصطلحات موضوعية: Models, Molecular, T cell, CD8-Positive T-Lymphocytes, Pharmacology, GPI-Linked Proteins, 01 natural sciences, Small Molecule Libraries, Mice, Structure-Activity Relationship, 03 medical and health sciences, Immune system, Pharmacokinetics, Drug Discovery, medicine, Extracellular, Animals, Humans, Structure–activity relationship, 5'-Nucleotidase, 030304 developmental biology, 0303 health sciences, Tumor microenvironment, Binding Sites, Chemistry, Catabolism, Haplorhini, Adenosine, Rats, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, medicine.anatomical_structure, Leukocytes, Mononuclear, Molecular Medicine, Protein Binding, medicine.drug
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bb2a8967687083bf528bd8c33e2866fTest
https://doi.org/10.1021/acs.jmedchem.0c00525Test -
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المؤلفون: Stephen W Young, Debashis Mandal, Sharon Zhao, Susanne Moschütz, Ada Chen, Elaine Ginn, Lixia Jin, Samuel L Drew, Nigel Walker, Erick Allen Lindsey, Jay P. Powers, Kenneth V. Lawson, Xuelei Yan, Anh Tran, Rhiannon Thomas-Tran, Amber Pham, Manmohan Reddy Leleti, Jenna L. Jeffrey, Steven D. Jacob, Norbert Sträter, Joel W. Beatty, Jeremy Fournier, Laurent Debien
المصدر: Journal of Medicinal Chemistry. 63:3935-3955
مصطلحات موضوعية: Membrane permeability, Stereochemistry, CHO Cells, Crystallography, X-Ray, GPI-Linked Proteins, Binding, Competitive, 01 natural sciences, 03 medical and health sciences, chemistry.chemical_compound, Cricetulus, Cricetinae, Drug Discovery, medicine, Animals, Humans, Nucleotide, 5'-Nucleotidase, Cells, Cultured, 030304 developmental biology, chemistry.chemical_classification, 0303 health sciences, Chemistry, Triazoles, Purinergic signalling, Adenosine, Small molecule, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Benzonitrile, Enzyme, Hepatocytes, Molecular Medicine, Nucleoside, medicine.drug
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cb1d479ddd330a628c6dc7fec984840Test
https://doi.org/10.1021/acs.jmedchem.9b01713Test -
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المؤلفون: Kenneth V. Lawson, Jenna L. Jeffrey, Jay P. Powers
المصدر: Journal of medicinal chemistry. 63(22)
مصطلحات موضوعية: Drug, media_common.quotation_subject, Antineoplastic Agents, GPI-Linked Proteins, 01 natural sciences, Protein Structure, Secondary, 03 medical and health sciences, Drug Delivery Systems, Drug Discovery, medicine, Extracellular, Humans, Ectonucleotidase, Nucleotide, Enzyme Inhibitors, 5'-Nucleotidase, 030304 developmental biology, media_common, chemistry.chemical_classification, 0303 health sciences, Tumor microenvironment, Nucleotides, Apyrase, Metabolism, Adenosine, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Enzyme, chemistry, Cancer research, Molecular Medicine, medicine.drug
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c6d695fef9e6b1a7341abf8389d4b35Test
https://pubmed.ncbi.nlm.nih.gov/32786396Test